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Ranitidine reduced levodopa-induced dyskinesia in a rat model of Parkinson’s disease

Overview of attention for article published in Neuropsychiatric Disease and Treatment, December 2013
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Mentioned by

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2 tweeters

Citations

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22 Mendeley
Title
Ranitidine reduced levodopa-induced dyskinesia in a rat model of Parkinson’s disease
Published in
Neuropsychiatric Disease and Treatment, December 2013
DOI 10.2147/ndt.s54782
Pubmed ID
Authors

Yang, Guiyun Cui, Xiaoying Wang, Xuanye Yue, Hongjuan Shi, Xia Shen, Zunsheng Zhang

Abstract

Chronic administration of levodopa in Parkinson's disease leads to debilitating involuntary movements, termed levodopa-induced dyskinesia (LID). The pathogenesis of LID is poorly understood. Previous research has shown that histamine H2 receptors are highly expressed in the input (striatum) and output (globus pallidus, substantia nigra) regions of the basal ganglia, particularly in the GABAergic striatopallidal and striatonigral pathways. Therefore, a histamine H2 receptor antagonist could be used to reduce LID. In the present work, we investigated whether ranitidine has the potential to diminish LID in rats with dyskinesia and explored the underlying mechanisms involved.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 27%
Student > Master 4 18%
Student > Bachelor 2 9%
Student > Doctoral Student 2 9%
Researcher 2 9%
Other 2 9%
Unknown 4 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 23%
Medicine and Dentistry 4 18%
Business, Management and Accounting 2 9%
Neuroscience 2 9%
Nursing and Health Professions 1 5%
Other 1 5%
Unknown 7 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2014.
All research outputs
#9,126,658
of 14,535,828 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,488
of 2,442 outputs
Outputs of similar age
#135,516
of 257,185 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#58
of 92 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,185 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.