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Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

Overview of attention for article published in OncoTargets and therapy, December 2013
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
108 Mendeley
Title
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
Published in
OncoTargets and therapy, December 2013
DOI 10.2147/ott.s38111
Pubmed ID
Authors

Albrecht Neesse, Thomas M. Gress, David A. Tuveson, Patrick Michl, Sebastian Krug

Abstract

Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular matrix collaboratively interact within the tumor microenvironment, sustaining and driving cancer cell proliferation, invasion, and early metastasis. More recently, the tumor microenvironment has also been appreciated to mediate therapeutic resistance in pancreatic ductal adenocarcinoma, thus opening numerous avenues for novel therapeutic explorations. Inert and soluble components of the tumor stroma have been targeted in order to break down the extracellular matrix scaffold, relieve vessel compression, and increase drug delivery to hypovascular tumors. Moreover, targeting of antiapoptotic, immunosuppressive, and pro-proliferative effects of the tumor stroma provides novel vantage points of attack. This review focuses on current and future developments in pancreatic cancer medicine, with a particular emphasis on biophysical and biochemical approaches that target the tumor microenvironment.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 3 3%
Germany 1 <1%
China 1 <1%
United States 1 <1%
Unknown 102 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 34%
Researcher 27 25%
Student > Doctoral Student 11 10%
Student > Master 8 7%
Other 7 6%
Other 18 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 29%
Medicine and Dentistry 29 27%
Biochemistry, Genetics and Molecular Biology 24 22%
Engineering 8 7%
Unspecified 6 6%
Other 10 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2015.
All research outputs
#7,522,386
of 12,475,053 outputs
Outputs from OncoTargets and therapy
#416
of 1,548 outputs
Outputs of similar age
#114,722
of 236,138 outputs
Outputs of similar age from OncoTargets and therapy
#7
of 33 outputs
Altmetric has tracked 12,475,053 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,548 research outputs from this source. They receive a mean Attention Score of 2.4. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,138 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.