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Nitric oxide-loaded echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage

Overview of attention for article published in International Journal of Nanomedicine, December 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
35 Mendeley
Title
Nitric oxide-loaded echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage
Published in
International Journal of Nanomedicine, December 2013
DOI 10.2147/ijn.s48856
Pubmed ID
Authors

Shao-Ling Huang, Hyunggun Kim, George Britton, Tao Peng, Holland, David McPherson

Abstract

Delayed cerebral vasospasm following subarachnoid hemorrhage causes severe ischemic neurologic deficits leading to permanent neurologic dysfunction or death. Reduced intravascular and perivascular nitric oxide (NO) availability is a primary pathophysiology of cerebral vasospasm. In this study, we evaluated NO-loaded echogenic liposomes (NO-ELIP) for ultrasound-facilitated NO delivery to produce vasodilation for treatment of vasospasm following subarachnoid hemorrhage. We investigated the vasodilative effects of NO released from NO-ELIP both ex vivo and in vivo. Liposomes containing phospholipids and cholesterol were prepared, and NO was encapsulated. The encapsulation and release of NO from NO-ELIP were determined by the syringe/vacuum method and ultrasound imaging. The ex vivo vasodilative effect of NO-ELIP was investigated using rabbit carotid arteries. Arterial vasodilation was clearly observed with NO-ELIP exposed to Doppler ultrasound whereas there was little vasodilative effect without exposure to Doppler ultrasound in the presence of red blood cells. Penetration of NO into the arterial wall was determined by fluorescent microscopy. The vasodilative effects of intravenously administered NO-ELIP in vivo were determined in a rat subarachnoid hemorrhage model. NO-ELIP with ultrasound activation over the carotid artery demonstrated effective arterial vasodilation in vivo resulting in improved neurologic function. This novel methodology for ultrasound-controlled delivery of NO has the potential for therapeutic treatment of vasospasm following subarachnoid hemorrhage. This ultrasound-controlled release strategy provides a new avenue for targeted bioactive gas and therapeutic delivery for improved stroke treatment.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 6%
Japan 1 3%
Unknown 32 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 23%
Student > Ph. D. Student 5 14%
Student > Master 5 14%
Professor > Associate Professor 3 9%
Student > Doctoral Student 3 9%
Other 4 11%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 8 23%
Engineering 7 20%
Agricultural and Biological Sciences 3 9%
Chemistry 2 6%
Physics and Astronomy 1 3%
Other 3 9%
Unknown 11 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2014.
All research outputs
#3,761,818
of 9,046,354 outputs
Outputs from International Journal of Nanomedicine
#285
of 1,977 outputs
Outputs of similar age
#59,993
of 184,893 outputs
Outputs of similar age from International Journal of Nanomedicine
#9
of 123 outputs
Altmetric has tracked 9,046,354 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 1,977 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.