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Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule

Overview of attention for article published in International Journal of Nanomedicine, December 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

dimensions_citation
53 Dimensions

Readers on

mendeley
111 Mendeley
citeulike
1 CiteULike
Title
Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule
Published in
International Journal of Nanomedicine, December 2013
DOI 10.2147/ijn.s54529
Pubmed ID
Authors

Young Choi, Sang Gon Lee, Jae Han Jeong, Kyung Min Lee, Kyu Ho Jeong, Huisuk Yang, Miroo Kim, Hyungil Jung, Sangkil Lee

Abstract

Nanostructured lipid carriers (NLCs) were employed to formulate a lipophilic drug into hydrophilic polymeric microneedles (MNs). Hyaluronic acid (HA) was selected as a hydrophilic and bioerodible polymer to fabricate MNs, and nile red (NR) was used as a model lipophilic molecule. NR-loaded NLCs were consolidated into the HA-based MNs to prepare NLC-loaded MNs (NLC-MNs). A dispersion of NLCs was prepared by high-pressure homogenization after dissolving NR in Labrafil and mixing with melted Compritol, resulting in 268 nm NLCs with a polydispersity index of 0.273. The NLC dispersion showed a controlled release of NR over 24 hours, following Hixson-Crowell's cube root law. After mixing the NLC dispersion with the HA solution, the drawing lithography method was used to fabricate NLC-MNs. The length, base diameter, and tip diameter of the NLC-MNs were approximately 350, 380, and 30 μm, respectively. Fluorescence microscopic imaging of the NLC-MNs helped confirm that the NR-loaded NLCs were distributed evenly throughout the MNs. In a skin permeation study performed using a Franz diffusion cell with minipig dorsal skin, approximately 70% of NR was localized in the skin after 24-hour application of NLC-MNs. Confocal laser scanning microscopy (z-series) of the skin at different depths showed strong fluorescence intensity in the epidermal layer, which appeared to spread out radially with the passage of time. This study indicated that incorporation of drug-loaded NLCs into MNs could represent a promising strategy for controlled dermal delivery of lipophilic drugs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
India 2 2%
United Kingdom 2 2%
Russia 1 <1%
Serbia 1 <1%
Unknown 103 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 23%
Student > Master 23 21%
Researcher 17 15%
Student > Postgraduate 11 10%
Student > Doctoral Student 7 6%
Other 12 11%
Unknown 15 14%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 30 27%
Agricultural and Biological Sciences 14 13%
Chemistry 12 11%
Medicine and Dentistry 12 11%
Physics and Astronomy 5 5%
Other 18 16%
Unknown 20 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2020.
All research outputs
#5,233,559
of 17,359,532 outputs
Outputs from International Journal of Nanomedicine
#532
of 3,177 outputs
Outputs of similar age
#76,979
of 273,454 outputs
Outputs of similar age from International Journal of Nanomedicine
#25
of 123 outputs
Altmetric has tracked 17,359,532 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,177 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,454 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.