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Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, January 2014
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  • Average Attention Score compared to outputs of the same age

Mentioned by

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2 tweeters

Citations

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41 Dimensions

Readers on

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59 Mendeley
Title
Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles
Published in
International Journal of Nanomedicine, January 2014
DOI 10.2147/ijn.s54226
Pubmed ID
Authors

Kai Zhao, Yang Zhang, Xiaoyan Zhang, Wei Li, Ci Shi, Chen Guo, Chunxiao Dai, Qian Chen, Zheng Jin, Yan Zhao, Yunfeng Wang, Hongyu Cui

Abstract

Optimal preparation conditions of Newcastle disease virus (NDV) F gene deoxyribonucleic acid (DNA) vaccine encapsulated in chitosan nanoparticles (pFNDV-CS-NPs) were determined. The pFNDV-CS-NPs were prepared according to a complex coacervation method. The pFNDV-CS-NPs were produced with good morphology, high stability, a mean diameter of 199.5 nm, encapsulation efficiency of 98.37% ± 0.87%, loading capacity of 36.12% ± 0.19%, and a zeta potential of +12.11 mV. The in vitro release assay showed that the plasmid DNA was sustainably released from the pFNDV-CS-NPs, up to 82.9% ± 2.9% of the total amount. Cell transfection test indicated that the vaccine expressed the F gene in cells and maintained good bioactivity. Additionally, the safety of mucosal immunity delivery system of the pFNDV-CS-NPs was also tested in vitro by cell cytotoxicity and in vivo by safety test in chickens. In vivo immunization showed that better immune responses of specific pathogen-free chickens immunized with the pFNDV-CS-NPs were induced, and prolonged release of the plasmid DNA was achieved compared to the chickens immunized with the control plasmid. This study lays the foundation for the further development of mucosal vaccines and drugs encapsulated in chitosan nanoparticles.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 25%
Student > Bachelor 9 15%
Student > Master 9 15%
Researcher 5 8%
Student > Doctoral Student 4 7%
Other 6 10%
Unknown 11 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 22%
Chemistry 6 10%
Immunology and Microbiology 6 10%
Veterinary Science and Veterinary Medicine 5 8%
Engineering 3 5%
Other 10 17%
Unknown 16 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2014.
All research outputs
#2,910,495
of 4,507,509 outputs
Outputs from International Journal of Nanomedicine
#712
of 1,146 outputs
Outputs of similar age
#76,334
of 122,890 outputs
Outputs of similar age from International Journal of Nanomedicine
#95
of 125 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,890 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.