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Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent

Citations

dimensions_citation
60 Dimensions

Readers on

mendeley
81 Mendeley
Title
Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles
Published in
International Journal of Nanomedicine, January 2014
DOI 10.2147/ijn.s54226
Pubmed ID
Authors

Kai Zhao, Yang Zhang, Xiaoyan Zhang, Wei Li, Ci Shi, Chen Guo, Chunxiao Dai, Qian Chen, Zheng Jin, Yan Zhao, Yunfeng Wang, Hongyu Cui

Abstract

Optimal preparation conditions of Newcastle disease virus (NDV) F gene deoxyribonucleic acid (DNA) vaccine encapsulated in chitosan nanoparticles (pFNDV-CS-NPs) were determined. The pFNDV-CS-NPs were prepared according to a complex coacervation method. The pFNDV-CS-NPs were produced with good morphology, high stability, a mean diameter of 199.5 nm, encapsulation efficiency of 98.37% ± 0.87%, loading capacity of 36.12% ± 0.19%, and a zeta potential of +12.11 mV. The in vitro release assay showed that the plasmid DNA was sustainably released from the pFNDV-CS-NPs, up to 82.9% ± 2.9% of the total amount. Cell transfection test indicated that the vaccine expressed the F gene in cells and maintained good bioactivity. Additionally, the safety of mucosal immunity delivery system of the pFNDV-CS-NPs was also tested in vitro by cell cytotoxicity and in vivo by safety test in chickens. In vivo immunization showed that better immune responses of specific pathogen-free chickens immunized with the pFNDV-CS-NPs were induced, and prolonged release of the plasmid DNA was achieved compared to the chickens immunized with the control plasmid. This study lays the foundation for the further development of mucosal vaccines and drugs encapsulated in chitosan nanoparticles.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 81 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 22%
Student > Master 10 12%
Researcher 8 10%
Student > Bachelor 7 9%
Unspecified 6 7%
Other 14 17%
Unknown 18 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 21%
Chemistry 9 11%
Veterinary Science and Veterinary Medicine 6 7%
Immunology and Microbiology 6 7%
Unspecified 5 6%
Other 16 20%
Unknown 22 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2022.
All research outputs
#6,466,487
of 22,950,943 outputs
Outputs from International Journal of Nanomedicine
#690
of 3,830 outputs
Outputs of similar age
#76,479
of 306,323 outputs
Outputs of similar age from International Journal of Nanomedicine
#21
of 102 outputs
Altmetric has tracked 22,950,943 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,830 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,323 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.