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Umbilical cord mesenchymal stem cells labeled with multimodal iron oxide nanoparticles with fluorescent and magnetic properties: application for in vivo cell tracking

Overview of attention for article published in International Journal of Nanomedicine, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
32 Mendeley
Title
Umbilical cord mesenchymal stem cells labeled with multimodal iron oxide nanoparticles with fluorescent and magnetic properties: application for in vivo cell tracking
Published in
International Journal of Nanomedicine, January 2014
DOI 10.2147/ijn.s53299
Pubmed ID
Authors

Lionel Gamarra, Tatiana Sibov, Lorena Pavon, Liza Miyaki, Javier Mamani, Leopoldo Nucci, Larissa Alvarim, Paulo Silveira, Luciana Marti

Abstract

Here we describe multimodal iron oxide nanoparticles conjugated to Rhodamine-B (MION-Rh), their stability in culture medium, and subsequent validation of an in vitro protocol to label mesenchymal stem cells from umbilical cord blood (UC-MSC) with MION-Rh. These cells showed robust labeling in vitro without impairment of their functional properties, the viability of which were evaluated by proliferation kinetic and ultrastructural analyzes. Thus, labeled cells were infused into striatum of adult male rats of animal model that mimic late onset of Parkinson's disease and, after 15 days, it was observed that cells migrated along the medial forebrain bundle to the substantia nigra as hypointense spots in T2 magnetic resonance imaging. These data were supported by short-term magnetic resonance imaging. Studies were performed in vivo, which showed that about 5 × 10(5) cells could be efficiently detected in the short term following infusion. Our results indicate that these labeled cells can be efficiently tracked in a neurodegenerative disease model.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
India 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 22%
Researcher 6 19%
Student > Postgraduate 5 16%
Student > Master 5 16%
Professor 3 9%
Other 4 13%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 22%
Medicine and Dentistry 6 19%
Biochemistry, Genetics and Molecular Biology 5 16%
Engineering 2 6%
Physics and Astronomy 2 6%
Other 5 16%
Unknown 5 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2015.
All research outputs
#2,048,154
of 9,380,044 outputs
Outputs from International Journal of Nanomedicine
#135
of 2,031 outputs
Outputs of similar age
#41,101
of 192,586 outputs
Outputs of similar age from International Journal of Nanomedicine
#4
of 122 outputs
Altmetric has tracked 9,380,044 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,031 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,586 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.