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Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs

Overview of attention for article published in International Journal of Nanomedicine, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent
googleplus
1 Google+ user

Citations

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41 Dimensions

Readers on

mendeley
45 Mendeley
Title
Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs
Published in
International Journal of Nanomedicine, January 2014
DOI 10.2147/ijn.s56127
Pubmed ID
Authors

Gourapura Renukaradhya, Basavaraj Binjawadagi, Varun Dwivedi, Cordelia Manickam, Kang Ouyang, Yun Wu, James Lee, Jordi Torrelles

Abstract

Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is an economically devastating disease, causing daily losses of approximately $3 million to the US pork industry. Current vaccines have failed to completely prevent PRRS outbreaks. Recently, we have shown that poly(lactic-co-glycolic) acid (PLGA) nanoparticle-entrapped inactivated PRRSV vaccine (NP-KAg) induces a cross-protective immune response in pigs. To further improve its cross-protective efficacy, the NP-KAg vaccine formulation was slightly modified, and pigs were coadministered the vaccine twice intranasally with a potent adjuvant: Mycobacterium tuberculosis whole-cell lysate. In vaccinated virulent heterologous PRRSV-challenged pigs, the immune correlates in the blood were as follows: 1) enhanced PRRSV-specific antibody response with enhanced avidity of both immunoglobulin (Ig)-G and IgA isotypes, associated with augmented virus-neutralizing antibody titers; 2) comparable and increased levels of virus-specific IgG₁ and IgG₂ antibody subtypes and production of high levels of both T-helper (Th)-1 and Th2 cytokines, indicative of a balanced Th1-Th2 response; 3) suppressed immunosuppressive cytokine response; 4) increased frequency of interferon-γ(+) lymphocyte subsets and expanded population of antigen-presenting cells; and most importantly 5) complete clearance of detectable replicating challenged heterologous PRRSV and close to threefold reduction in viral ribonucleic acid load detected in the blood. In conclusion, intranasal delivery of adjuvanted NP-KAg vaccine formulation to growing pigs elicited a broadly cross-protective immune response, showing the potential of this innovative vaccination strategy to prevent PRRS outbreaks in pigs. A similar approach to control other respiratory diseases in food animals and humans appears to be feasible.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 7%
Denmark 2 4%
United States 2 4%
Unknown 38 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 22%
Student > Master 10 22%
Student > Ph. D. Student 7 16%
Student > Doctoral Student 4 9%
Other 3 7%
Other 9 20%
Unknown 2 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 38%
Immunology and Microbiology 4 9%
Veterinary Science and Veterinary Medicine 4 9%
Nursing and Health Professions 3 7%
Social Sciences 3 7%
Other 10 22%
Unknown 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2020.
All research outputs
#4,117,738
of 16,822,220 outputs
Outputs from International Journal of Nanomedicine
#325
of 3,070 outputs
Outputs of similar age
#55,489
of 260,326 outputs
Outputs of similar age from International Journal of Nanomedicine
#11
of 121 outputs
Altmetric has tracked 16,822,220 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,070 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,326 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.