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Two grams of sarcosine in schizophrenia – is it too much? A potential role of glutamate- serotonin interaction

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

twitter
3 tweeters
wikipedia
1 Wikipedia page
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
61 Mendeley
citeulike
2 CiteULike
Title
Two grams of sarcosine in schizophrenia – is it too much? A potential role of glutamate- serotonin interaction
Published in
Neuropsychiatric Disease and Treatment, February 2014
DOI 10.2147/ndt.s54024
Pubmed ID
Authors

Dominik Strzelecki, Justyna Szyburska, Jolanta Rabe-Jabłońska

Abstract

Glutamate is the main excitatory neurotransmitter in the central nervous system. Dysfunction of the glutamatergic system plays an important role in the pathogenesis of schizophrenia. Therefore, glutamatergic agents such as N-methyl-D-aspartate receptor co-agonists (ie, glycine, D-cycloserine) and glycine transporter type 1 inhibitors (eg, sarcosine) are studied for their efficacy in ameliorating negative and cognitive symptomatology in patients with schizophrenia. We report the case of a 23-year-old schizophrenic patient treated with quetiapine and citalopram, who was offered concomitant sarcosine treatment. After obtaining an informed consent, we started administration of 2 g of sarcosine per day to treat persistent negative and cognitive symptoms. The patient's activity and mood improved within 2 weeks, but in the following 2 weeks the patient reported increased drive, activity, libido, unpleasant inner tension, and irritability. We ruled out hypomania and decided to decrease the daily dose of sarcosine to 1 g, which resulted in reduction of drive and irritability. Activity and mood improved compared with his state before adding sarcosine. We suggest a sarcosine dose between 1 g and 2 g per day with an initial dose of 2 g, but if side effects occur, the dose should be decreased to 1 g per day. We would like to emphasize the clinically important glutamate-serotonin interaction during concomitant use of sarcosine, citalopram, and quetiapine in our patient, which may lead to serious discomfort.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 21%
Researcher 11 18%
Student > Master 9 15%
Professor > Associate Professor 8 13%
Student > Ph. D. Student 5 8%
Other 9 15%
Unknown 6 10%
Readers by discipline Count As %
Medicine and Dentistry 16 26%
Psychology 8 13%
Agricultural and Biological Sciences 8 13%
Biochemistry, Genetics and Molecular Biology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 11 18%
Unknown 11 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2017.
All research outputs
#4,737,031
of 19,606,303 outputs
Outputs from Neuropsychiatric Disease and Treatment
#626
of 2,785 outputs
Outputs of similar age
#57,922
of 273,982 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#17
of 97 outputs
Altmetric has tracked 19,606,303 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,785 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,982 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.