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High glucose levels promote the proliferation of breast cancer cells through GTPases

Overview of attention for article published in Breast cancer targets and therapy, June 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 184)
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
20 tweeters
facebook
11 Facebook pages
googleplus
2 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
22 Dimensions

Readers on

mendeley
29 Mendeley
Title
High glucose levels promote the proliferation of breast cancer cells through GTPases
Published in
Breast cancer targets and therapy, June 2017
DOI 10.2147/bctt.s135665
Pubmed ID
Authors

Yilin Hou, Man Zhou, Jing Xie, Ping Chao, Qiyu Feng, Jun Wu

Abstract

Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high glucose levels promote the proliferation of breast cancer cells by stimulating epidermal growth factor receptor (EGFR) activation and the Rho family GTPase Rac1 and Cdc42 mediate the corresponding signaling induced by high glucose levels. We further show that Cdc42 promotes EGFR phosphorylation by blocking EGFR degradation, which may be mediated by the Cbl proteins, whereas the Rac1-mediated EGFR phosphorylation is independent of EGFR degradation. Our findings elucidate a part of the underlying molecular mechanism of the link between high glucose levels and tumorigenesis in breast cancer and may provide new insights on the therapeutic strategy for cancer patients with diabetes or hyperglycemia.

Twitter Demographics

The data shown below were collected from the profiles of 20 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 24%
Student > Bachelor 6 21%
Researcher 4 14%
Other 3 10%
Student > Master 3 10%
Other 3 10%
Unknown 3 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 34%
Medicine and Dentistry 4 14%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Agricultural and Biological Sciences 3 10%
Nursing and Health Professions 1 3%
Other 5 17%
Unknown 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2020.
All research outputs
#1,077,979
of 15,760,851 outputs
Outputs from Breast cancer targets and therapy
#13
of 184 outputs
Outputs of similar age
#29,674
of 271,712 outputs
Outputs of similar age from Breast cancer targets and therapy
#4
of 12 outputs
Altmetric has tracked 15,760,851 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 184 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,712 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.