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Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, June 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

twitter
5 tweeters
facebook
1 Facebook page

Citations

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72 Dimensions

Readers on

mendeley
60 Mendeley
Title
Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD
Published in
International Journal of Chronic Obstructive Pulmonary Disease, June 2017
DOI 10.2147/copd.s129787
Pubmed ID
Authors

maeva zysman, Gaétan Deslee, denis caillaud, pascal chanez, roger escamilla, isabelle court-fortune, pascale nesme-meyer, thierry perez, jean-louis paillasseur, christophe pinet, gilles jebrak, nicolas roche, pierre-regis burgel

Abstract

In patients with COPD, there is controversy regarding the association of blood eosinophil (Eos) levels with 1) exacerbation frequency and 2) the effect of inhaled corticosteroids for prevention of exacerbations. To determine whether Eos define subgroups of patients exhibiting attributes of COPD clinical phenotypes, we compared clinical features and mortality rates in COPD patients from the Initiatives BPCO French cohort categorized using different thresholds of blood Eos levels. The following data were collected at inclusion: medical and smoking history, occupational exposures, dyspnea, cough and sputum production, exacerbations in the previous year, history of allergy and asthma, nasal symptoms, body mass index, St George Respiratory Questionnaire (SGRQ) total score, post-bronchodilator spirometry, comorbidities, and medications. Three-year survival between groups was compared using Kaplan-Meier analysis. Three sets of analyses were performed to compare patients with ≥2% versus <2%, ≥3% versus <3%, and ≥4% versus <4% Eos. Eos was available in 458 patients (mean age: 62 years, 72% male, mean forced expiratory volume in 1 second: 51% pred), including 235 patients with Eos ≥2% (49%), 149 with Eos ≥3% (33%), and 90 with Eos ≥4% (20%). For all cutoffs, there was no difference between Eos+ and Eos- groups in univariate analyses except for diabetes and SGRQ score (more frequent and more impaired, respectively, in lower Eos categories). In particular, there was no difference in exacerbation rate, history of asthma, or three-year survival. In conclusion, regardless of the cutoff, Eos+ COPD patients exhibited no specific characteristic in terms of symptoms, lung function, exacerbation rate, and prognosis. These findings suggest that the association of higher Eos with exacerbations reported in previous studies could be population specific, which does not support generalizing the use of Eos as a biomarker for COPD phenotyping.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Master 7 12%
Other 6 10%
Professor 5 8%
Student > Ph. D. Student 5 8%
Other 11 18%
Unknown 13 22%
Readers by discipline Count As %
Medicine and Dentistry 26 43%
Nursing and Health Professions 4 7%
Agricultural and Biological Sciences 2 3%
Arts and Humanities 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 6 10%
Unknown 20 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2017.
All research outputs
#6,888,645
of 21,257,749 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#861
of 2,214 outputs
Outputs of similar age
#106,347
of 285,091 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#28
of 63 outputs
Altmetric has tracked 21,257,749 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,214 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,091 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.