↓ Skip to main content

Dove Medical Press

Article Metrics

Autophagy regulates the stemness of cervical cancer stem cells

Overview of attention for article published in Biologics: Targets & Therapy, June 2017
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
27 Mendeley
Title
Autophagy regulates the stemness of cervical cancer stem cells
Published in
Biologics: Targets & Therapy, June 2017
DOI 10.2147/btt.s134920
Pubmed ID
Authors

Yi Yang, Li Yu, Jin Li, Ya Hong Yuan, Xiao Li Wang, Shi Rong Yan, Dong Sheng Li, Yan Ding, Yang, Yi, Yu, Li, Li, Jin, Yuan, Ya Hong, Wang, Xiao Li, Yan, Shi Rong, Li, Dong Sheng, Ding, Yan

Abstract

Cancer stem cells (CSCs) are a rare population of multipotent cells with the capacity to self-renew. It has been reported that there are CSCs in cervical cancer cells. Pluripotency-associated (PA) transcription factors such as Oct4, Sox2, Nanog and CD44 have been used to isolate CSCs subpopulations. In this study, we showed that autophagy plays an important role in the biological behavior of cervical cancer cells. The expression of the autophagy protein Beclin 1 and LC3B was higher in tumorspheres established from human cervical cancers cell lines (and CaSki) than in the parental adherent cells. It was also observed that the basal and starvation-induced autophagy flux was higher in tumorspheres than in the bulk population. Autophagy could regulate the expression level of PA proteins in cervical CSCs. In addition, CRISPR/Cas 9-mediated Beclin 1 knockout enhanced the malignancy of HeLa cells, leading to accumulation of PA proteins and promoted tumorsphere formation. Our findings suggest that autophagy modulates homeostasis of PA proteins, and Beclin 1 is critical for CSC maintenance and tumor development in nude mice. This demonstrates that a prosurvival autophagic pathway is critical for CSC maintenance.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Student > Bachelor 5 19%
Other 3 11%
Student > Doctoral Student 2 7%
Student > Ph. D. Student 1 4%
Other 1 4%
Unknown 9 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 41%
Agricultural and Biological Sciences 3 11%
Medicine and Dentistry 2 7%
Computer Science 1 4%
Unknown 10 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2017.
All research outputs
#6,580,721
of 11,747,817 outputs
Outputs from Biologics: Targets & Therapy
#96
of 188 outputs
Outputs of similar age
#122,195
of 267,865 outputs
Outputs of similar age from Biologics: Targets & Therapy
#1
of 2 outputs
Altmetric has tracked 11,747,817 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 188 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,865 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them