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Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis

Overview of attention for article published in Clinical and Experimental Gastroenterology, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#39 of 215)
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

twitter
1 tweeter
patent
3 patents

Readers on

mendeley
17 Mendeley
Title
Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis
Published in
Clinical and Experimental Gastroenterology, January 2014
DOI 10.2147/ceg.s51923
Pubmed ID
Authors

Ram Gupta, Avinash Jadhav, Shitalkumar Zambad, Ramesh Gupta, Shailesh Deshpande, Vijay Chauthaiwale, Chaitanya Dutt, Anita Chaudhary, Binita Shah

Abstract

Mucosal healing in inflammatory bowel disease (IBD) can be achieved by improvement of intestinal barrier protection. Activation of hypoxia-inducible factor (HIF) has been identified as a critical factor for barrier protection during mucosal insult and is linked with improvement in symptoms of colitis. Although prophylactic efficacy of HIF hydroxylase inhibitors in murine colitis have been established, its therapeutic efficacy in clinically relevant therapeutic settings have not been established. In the present study we aim to establish therapeutic efficacy of TRC160334, a novel HIF hydroxylase inhibitor, in animal models of colitis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 24%
Student > Master 4 24%
Student > Postgraduate 3 18%
Other 2 12%
Student > Bachelor 1 6%
Other 2 12%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 7 41%
Pharmacology, Toxicology and Pharmaceutical Science 3 18%
Agricultural and Biological Sciences 2 12%
Biochemistry, Genetics and Molecular Biology 2 12%
Chemistry 1 6%
Other 0 0%
Unknown 2 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2019.
All research outputs
#2,763,721
of 14,995,637 outputs
Outputs from Clinical and Experimental Gastroenterology
#39
of 215 outputs
Outputs of similar age
#36,717
of 188,859 outputs
Outputs of similar age from Clinical and Experimental Gastroenterology
#1
of 7 outputs
Altmetric has tracked 14,995,637 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 215 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,859 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them