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Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder

Overview of attention for article published in Neuropsychiatric Disease and Treatment, June 2017
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2 tweeters
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1 Facebook page

Citations

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31 Dimensions

Readers on

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34 Mendeley
Title
Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
Published in
Neuropsychiatric Disease and Treatment, June 2017
DOI 10.2147/ndt.s129081
Pubmed ID
Authors

Xiaosong Bu, De Wu, Xiaomei Lu, Li Yang, Xiaoyan Xu, Juan Wang, Jiulai Tang

Abstract

Autistic spectrum disorder (ASD) is a neurodevelopmental disorder and has a high prevalence in children. Recently, mitochondrial oxidative stress has been proposed to be associated with ASD. Besides, SIRT1/PGC-1α signaling plays an important role in combating oxidative stress. In this study, we sought to determine the role of SIRT1/PGC-1α signaling in the ASD lymphoblastoid cell lines (LCLs). In this study, the mRNA and protein expressions of SIRT1/PGC-1α axis genes were assessed in 35 children with ASD and 35 healthy controls (matched for age, gender, and IQ). An immortalized LCL was established by transforming lymphocytes with Epstein-Barr virus. Next, we used ASD LCLs and control LCLs to detect SIRT1/PGC-1α axis genes expression and oxidative damage. Finally, the effect of overexpression of PGC-1α on oxidative injury in the ASD LCLs was determined. SIRT1/PGC-1α axis genes expression was downregulated at RNA and protein levels in ASD patients and LCLs. Besides, the translocation of cytochrome c and DIABLO from mitochondria to the cytosol was found in the ASD LCLs. Moreover, the intracellular reactive oxygen species (ROS) and mitochondrial ROS and cell apoptosis were increased in the ASD LCLs. However, overexpression of PGC-1α upregulated the SIRT1/PGC-1α axis genes expression and reduced cytochrome c and DIABLO release in the ASD LCLs. Also, overexpression of PGC-1α reduced the ROS generation and cell apoptosis in the ASD LCLs. Overexpression of PGC-1α could reduce the oxidative injury in the ASD LCLs, and PGC-1α may act as a target for treatment.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 29%
Student > Ph. D. Student 6 18%
Student > Postgraduate 3 9%
Researcher 3 9%
Student > Doctoral Student 1 3%
Other 4 12%
Unknown 7 21%
Readers by discipline Count As %
Neuroscience 6 18%
Biochemistry, Genetics and Molecular Biology 5 15%
Psychology 3 9%
Social Sciences 2 6%
Medicine and Dentistry 2 6%
Other 7 21%
Unknown 9 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2021.
All research outputs
#14,933,120
of 22,203,123 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,752
of 2,928 outputs
Outputs of similar age
#176,904
of 287,305 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#51
of 90 outputs
Altmetric has tracked 22,203,123 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,928 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,305 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.