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Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant

Overview of attention for article published in International Journal of Nanomedicine, July 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
20 Mendeley
Title
Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant
Published in
International Journal of Nanomedicine, July 2017
DOI 10.2147/ijn.s132456
Pubmed ID
Authors

JiHui Zhao, Qi-Bo Zhang, Bao Liu, Xiang-Hua Piao, Yu-Lu Yan, Xiao-Ge Hu, Kuan Zhou, Yong-Tai Zhang, Nian-Ping Feng

Abstract

To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their uptake behavior, toxicity to mouse bone marrow dendritic cells (BMDCs), and hemolytic activity to rabbit red blood cells (RBCs) were evaluated. The OVA-PD-Lipos were incorporated into a dissolving microneedle array. The chemical stability of OVA and the physical stability of OVA-PD-Lipos in microneedle arrays were investigated. The immune response of Institute of Cancer Research mice and potential skin irritation reaction of rabbits to OVA-PD-Lipos-MNs were evaluated. The uptake of OVA by mouse BMDCs was greatly enhanced when OVA was prepared as OVA-PD-Lipos, and in this form, the toxicity of PD was dramatically reduced. OVA was chemically stable as OVA-PD-Lipos, when OVA-PD-Lipos was incorporated into a dissolving microneedle array. Institute of Cancer Research mice treated with OVA-PD-Lipos-MNs showed a significantly enhanced immune response. PD combined with OVA elicited a balanced Th1 and Th2 humoral immune response in mice, with minimal irritation in rabbit skin. The dissolving microneedle array-based system is a promising delivery vehicle for subunit vaccine and its adjuvant.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 15%
Student > Master 3 15%
Student > Bachelor 2 10%
Student > Ph. D. Student 2 10%
Other 1 5%
Other 3 15%
Unknown 6 30%
Readers by discipline Count As %
Medicine and Dentistry 3 15%
Agricultural and Biological Sciences 2 10%
Chemical Engineering 1 5%
Business, Management and Accounting 1 5%
Immunology and Microbiology 1 5%
Other 3 15%
Unknown 9 45%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2019.
All research outputs
#4,083,054
of 15,037,508 outputs
Outputs from International Journal of Nanomedicine
#367
of 2,896 outputs
Outputs of similar age
#84,386
of 266,158 outputs
Outputs of similar age from International Journal of Nanomedicine
#4
of 54 outputs
Altmetric has tracked 15,037,508 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,896 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,158 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.