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Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, July 2017
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  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

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7 Dimensions

Readers on

mendeley
23 Mendeley
Title
Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers
Published in
International Journal of Chronic Obstructive Pulmonary Disease, July 2017
DOI 10.2147/copd.s138558
Pubmed ID
Authors

Laura Caram, Renata Ferrari, Duelene Ludimila Nogueira, Maria Regina Oliveira, Fabiane Francisqueti, Suzana Tanni, Camila Renata Corrêa, Irma De Godoy

Abstract

Oxidative stress and systemic inflammation are higher in smokers and patients with COPD; however, markers that may help differentiate between smokers and patients with COPD have not yet been identified. We hypothesized that tumor necrosis factor-alpha receptor (TNFR) and soluble form of the receptor for advanced glycation end products (sRAGE) can be indicators of COPD in asymptomatic patients. We evaluated 32 smokers (smoking history >10 pack-years), 32 patients with mild/moderate COPD (smokers and ex-smokers), and 32 never smokers. Concentrations of C-reactive protein (CRP), interleukin (IL)-6, TNFR1 and TNFR2, advanced glycation end products (AGEs), and the sRAGE were measured in serum. There were higher CRP and AGEs concentrations in smokers and in patients with COPD (P<0.001 and P=0.01, respectively) compared to controls, without statistical difference between smokers and patients with COPD. Concentrations of sRAGE, IL-6, and TNFR1 did not differ between study groups. TNFR2 was significantly higher in patients with COPD than in smokers (P=0.004) and controls (P=0.004), and the presence of COPD (P=0.02) and CRP (P=0.001) showed a positive association with TNFR2. Positive associations for smoking (P=0.04), CRP (P=0.03), and IL-6 (P=0.03) with AGEs were also found. The interaction variable (smoking × COPD) showed a positive association with IL-6. Our data suggest that TNFR2 may be a possible marker of COPD in asymptomatic smokers and ex-smokers. Although smokers and patients with early COPD presented other increased systemic inflammation markers (eg, CRP) and oxidative stress (measured by AGEs), they did not differentiate smokers from COPD.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 35%
Student > Ph. D. Student 3 13%
Professor 2 9%
Student > Bachelor 2 9%
Other 1 4%
Other 2 9%
Unknown 5 22%
Readers by discipline Count As %
Medicine and Dentistry 7 30%
Biochemistry, Genetics and Molecular Biology 6 26%
Agricultural and Biological Sciences 1 4%
Nursing and Health Professions 1 4%
Immunology and Microbiology 1 4%
Other 2 9%
Unknown 5 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2017.
All research outputs
#7,303,818
of 11,727,438 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#859
of 1,376 outputs
Outputs of similar age
#150,741
of 264,233 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#41
of 62 outputs
Altmetric has tracked 11,727,438 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,376 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,233 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.