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Assessment of sputum smear-positive but culture-negative results among newly diagnosed pulmonary tuberculosis patients in Tanzania

Overview of attention for article published in International Journal of General Medicine, July 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)

Mentioned by

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6 tweeters

Citations

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7 Dimensions

Readers on

mendeley
48 Mendeley
Title
Assessment of sputum smear-positive but culture-negative results among newly diagnosed pulmonary tuberculosis patients in Tanzania
Published in
International Journal of General Medicine, July 2017
DOI 10.2147/ijgm.s137469
Pubmed ID
Authors

Nicholaus Peter Mnyambwa, Esther S Ngadaya, Godfather Kimaro, Dong-Jin Kim, Rudovick Kazwala, Pammla Petrucka, Sayoki G Mfinanga, Mnyambwa, Nicholaus, Ngadaya, Esther, Kimaro, Godfather, Kim, Dong-Jin, Kazwala, Rudovick, Petrucka, Pammla, Mfinanga, Sayoki

Abstract

Diagnosis of pulmonary tuberculosis (TB) in technology-limited countries is widely achieved by smear microscopy, which has limited sensitivity and specificity. The frequency and clinical implication of smear-positive but culture-negative among presumptive TB patients remains unclear. A cross-sectional substudy was conducted which aimed to identify the proportion of nontuberculous mycobacteria (NTM) infections among 94 "smear-positive culture-negative" patients diagnosed between January 2013 and June 2016 in selected health facilities in Tanzania. Out of 94 sputa, 25 (26.60%) were GeneXpert® mycobacteria TB positive and 11/94 (11.70%) repeat-culture positive; 5 were Capilia TB-Neo positive and confirmed by GenoType MTBC to be Mycobacterium tuberculosis/Mycobacterium canettii. The remaining 6 Capilia TB-Neo negative samples were genotyped by GenoType® CM/AS, identifying 3 (3.19%) NTM, 2 Gram positive bacteria, and 1 isolate testing negative, together, making a total of 6/94 (6.38%) confirmed false smear-positives. Twenty-eight (29.79%) were confirmed TB cases, while 60 (63.83%) remained unconfirmed cases. Out of 6 (6.38%) patients who were HIV positive, 2 patients were possibly coinfected with mycobacteria. The isolation of NTM and other bacteria among smear-positive culture-negative samples and the presence of over two third of unconfirmed TB cases emphasize the need of both advanced differential TB diagnostic techniques and good clinical laboratory practices to avoid unnecessary administration of anti-TB drugs.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Student > Master 8 17%
Researcher 8 17%
Student > Bachelor 4 8%
Student > Postgraduate 4 8%
Other 7 15%
Unknown 8 17%
Readers by discipline Count As %
Medicine and Dentistry 15 31%
Immunology and Microbiology 6 13%
Biochemistry, Genetics and Molecular Biology 4 8%
Nursing and Health Professions 2 4%
Engineering 2 4%
Other 6 13%
Unknown 13 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2017.
All research outputs
#4,516,456
of 16,350,696 outputs
Outputs from International Journal of General Medicine
#132
of 510 outputs
Outputs of similar age
#85,121
of 268,447 outputs
Outputs of similar age from International Journal of General Medicine
#3
of 4 outputs
Altmetric has tracked 16,350,696 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 510 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,447 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.