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Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans

Overview of attention for article published in International Journal of Nanomedicine, June 2017
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

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4 tweeters

Citations

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23 Dimensions

Readers on

mendeley
45 Mendeley
Title
Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>
Published in
International Journal of Nanomedicine, June 2017
DOI 10.2147/ijn.s138790
Pubmed ID
Authors

Ying-Fei Yang, Yi-Jun Lin, Chung-Min Liao

Abstract

Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe(0)) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe(0)NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials. Here we present a TBTK/TD approach to appraise bioaccumulation and nanotoxicity of Fe(0)NPs in C. elegans. Built on a present C. elegans bioassay with estimated TBTK/TD parameters, we found that average bioconcentration factors in C. elegans exposed to waterborne and food-borne Fe(0)NPs were ~50 and ~5×10(-3), respectively, whereas 10% inhibition concentrations for fertility, locomotion, and development, were 1.26 (95% CI 0.19-5.2), 3.84 (0.38-42), and 6.78 (2.58-21) μg·g(-1), respectively, implicating that fertility is the most sensitive endpoint in C. elegans. Our results also showed that biomagnification effects were not observed in waterborne or food-borne Fe(0)NP-exposed worms. We suggest that the TBTK/TD assessment for predicting NP-induced toxicity at different concentrations and conditions in C. elegans could enable rapid selection of nanomaterials that are more likely to be nontoxic in larger animals. We conclude that the use of the TBTK/TD scheme manipulating C. elegans could be used for rapid evaluation of in vivo toxicity of NPs or for drug screening in the field of nanomedicine.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 18%
Student > Ph. D. Student 8 18%
Student > Doctoral Student 6 13%
Student > Bachelor 5 11%
Student > Master 5 11%
Other 6 13%
Unknown 7 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 16%
Agricultural and Biological Sciences 7 16%
Environmental Science 4 9%
Medicine and Dentistry 4 9%
Chemistry 2 4%
Other 8 18%
Unknown 13 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2017.
All research outputs
#6,887,648
of 11,511,689 outputs
Outputs from International Journal of Nanomedicine
#1,005
of 2,282 outputs
Outputs of similar age
#138,296
of 261,847 outputs
Outputs of similar age from International Journal of Nanomedicine
#17
of 54 outputs
Altmetric has tracked 11,511,689 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,282 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,847 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.