Title |
Near-infrared quantum dots for HER2 localization and imaging of cancer cells
|
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Published in |
International Journal of Nanomedicine, March 2014
|
DOI | 10.2147/ijn.s51535 |
Pubmed ID | |
Authors |
Sarwat B Rizvi, Sepideh Rouhi, Shohei Taniguchi, Shi Yu Yang, Mark Green, Mo Keshtgar, Alexander M Seifalian |
Abstract |
Quantum dots are fluorescent nanoparticles with unique photophysical properties that allow them to be used as diagnostic, therapeutic, and theranostic agents, particularly in medical and surgical oncology. Near-infrared-emitting quantum dots can be visualized in deep tissues because the biological window is transparent to these wavelengths. Their small sizes and free surface reactive groups that can be conjugated to biomolecules make them ideal probes for in vivo cancer localization, targeted chemotherapy, and image-guided cancer surgery. The human epidermal growth factor receptor 2 gene (HER2/neu) is overexpressed in 25%-30% of breast cancers. The current methods of detection for HER2 status, including immunohistochemistry and fluorescence in situ hybridization, are used ex vivo and cannot be used in vivo. In this paper, we demonstrate the application of near-infrared-emitting quantum dots for HER2 localization in fixed and live cancer cells as a first step prior to their in vivo application. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Poland | 1 | 1% |
Denmark | 1 | 1% |
Unknown | 81 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 19% |
Researcher | 15 | 18% |
Student > Master | 12 | 14% |
Student > Bachelor | 10 | 12% |
Student > Doctoral Student | 5 | 6% |
Other | 13 | 15% |
Unknown | 14 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 15% |
Medicine and Dentistry | 12 | 14% |
Agricultural and Biological Sciences | 11 | 13% |
Chemistry | 11 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Other | 16 | 19% |
Unknown | 17 | 20% |