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The association of tidal EFL with exercise performance, exacerbations, and death in COPD

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, July 2017
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Title
The association of tidal EFL with exercise performance, exacerbations, and death in COPD
Published in
International Journal of Chronic Obstructive Pulmonary Disease, July 2017
DOI 10.2147/copd.s138720
Pubmed ID
Authors

Bernt Boegvald Aarli, Peter MA Calverley, Robert Jensen, Raffaele L Dellacà, Tomas Mikal Eagan, Per Bakke, Jon Andrew Hardie

Abstract

Tidal expiratory flow limitation (EFLT) is frequently found in patients with COPD and can be detected by forced oscillations when within-breath reactance of a single-breath is ≥0.28 kPa·s·L(-1). The present study explored the association of within-breath reactance measured over multiple breaths and EFLT with 6-minute walk distance (6MWD), exacerbations, and mortality. In 425 patients, spirometry and forced oscillation technique measurements were obtained on eight occasions over 3 years. 6MWD was assessed at baseline and at the 3-year visit. Respiratory symptoms, exacerbations, and hospitalizations were recorded. A total of 5-year mortality statistics were retrieved retrospectively. We grouped patients according to the mean within-breath reactance [Formula: see text], measured over several breaths at baseline, calculated as mean inspiratory-mean expiratory reactance over the sampling period. In addition to the established threshold of EFLT, an upper limit of normal (ULN) was defined using the 97.5th percentile of [Formula: see text], of the healthy controls in the study; 6MWDs were compared according to [Formula: see text], as normal, ≥ ULN < EFLT, or ≥ EFLT. Annual exacerbation rates were analyzed using a negative binomial model in the three groups, supplemented by time to first exacerbation analysis, and dichotomizing patients at the ULN. In patients with COPD and baseline [Formula: see text] below the ULN (0.09 kPa·s·L(-1)), 6MWD was stable. 6MWD declined significantly in patients with [Formula: see text]. Worse lung function and more exacerbations were found in patients with COPD with [Formula: see text], and patients with [Formula: see text] had shorter time to first exacerbation and hospitalization. A significantly higher mortality was found in patients with [Formula: see text] and FEV1 >50%. Patients with baseline [Formula: see text] had a deterioration in exercise performance, more exacerbations, and greater hospitalizations, and, among those with moderate airway obstruction, a higher mortality. [Formula: see text] is a novel independent marker of outcome in COPD.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 29%
Researcher 4 24%
Unspecified 3 18%
Student > Bachelor 2 12%
Professor > Associate Professor 2 12%
Other 1 6%
Readers by discipline Count As %
Medicine and Dentistry 5 29%
Unspecified 4 24%
Nursing and Health Professions 3 18%
Engineering 3 18%
Psychology 1 6%
Other 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2018.
All research outputs
#10,305,023
of 12,913,752 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,267
of 1,572 outputs
Outputs of similar age
#194,940
of 265,092 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#50
of 55 outputs
Altmetric has tracked 12,913,752 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,572 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,092 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.