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Continual evolution of type 2 diabetes: an update on pathophysiology and emerging treatment options

Overview of attention for article published in Therapeutics and Clinical Risk Management, April 2015
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Title
Continual evolution of type 2 diabetes: an update on pathophysiology and emerging treatment options
Published in
Therapeutics and Clinical Risk Management, April 2015
DOI 10.2147/tcrm.s67387
Pubmed ID
Authors

Susan Cornell

Abstract

Diabetes is a complex and progressive disease that has a major societal and economic impact. The most common form of diabetes, type 2 diabetes mellitus (T2DM), is a multifactorial disease, the pathophysiology of which involves not only the pancreas but also the liver, skeletal muscle, adipose tissue, gastrointestinal tract, brain, and kidney. Novel therapies with mechanisms of action that are different from most existing drugs are emerging. One such class consists of compounds that inhibit renal sodium-glucose cotransporter 2, which is responsible for the bulk of glucose reabsorption by the kidneys. This new class of compounds improves glycemic control independently of insulin and promotes weight reduction, providing an additional tool to treat patients with T2DM. This review discusses the underlying pathophysiology of T2DM, clinical guidelines, and available and emerging treatment options, with particular emphasis on sodium-glucose cotransporter 2 inhibitors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 <1%
France 1 <1%
South Africa 1 <1%
Mexico 1 <1%
Russia 1 <1%
Spain 1 <1%
Unknown 233 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 51 21%
Student > Master 42 18%
Student > Ph. D. Student 22 9%
Researcher 15 6%
Other 14 6%
Other 27 11%
Unknown 69 29%
Readers by discipline Count As %
Medicine and Dentistry 62 26%
Agricultural and Biological Sciences 30 13%
Biochemistry, Genetics and Molecular Biology 27 11%
Nursing and Health Professions 14 6%
Pharmacology, Toxicology and Pharmaceutical Science 12 5%
Other 24 10%
Unknown 71 30%