Effect of heparan sulfate and gold nanoparticles on muscle development during embryogenesis
International Journal of Nanomedicine, December 2011
André Chwalibog, Zielinska, Ewa Sawosz, Grodzik, Wierzbicki, Gromadka, Anna Hotowy, Sawosz, Lozicki
It was hypothesized that heparan sulfate (HS) as an essential compound for myogenesis and nanoparticles of gold (nano-Au) as highly reactive compounds can affect muscle development as a consequence of molecular regulation of muscle cell formation, and that these effects may be enhanced by a complex of HS conjugated with nano-Au. The objective of the present study was to determine the effect of administration of nano-Au, HS, and a nano-Au+HS complex on the morphological and molecular characteristics of breast muscle during embryogenesis.
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