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Carbon nanotube-incorporated collagen hydrogels improve cell alignment and the performance of cardiac constructs

Overview of attention for article published in International Journal of Nanomedicine, April 2017
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Title
Carbon nanotube-incorporated collagen hydrogels improve cell alignment and the performance of cardiac constructs
Published in
International Journal of Nanomedicine, April 2017
DOI 10.2147/ijn.s128030
Pubmed ID
Authors

Hongyu Sun, Jing Zhou, Zhu Huang, Linlin Qu, Ning Lin, Chengxiao Liang, Ruiwu Dai, Lijun Tang, Fuzhou Tian

Abstract

Carbon nanotubes (CNTs) provide an essential 2-D microenvironment for cardiomyocyte growth and function. However, it remains to be elucidated whether CNT nanostructures can promote cell-cell integrity and facilitate the formation of functional tissues in 3-D hydrogels. Here, single-walled CNTs were incorporated into collagen hydrogels to fabricate (CNT/Col) hydrogels, which improved mechanical and electrical properties. The incorporation of CNTs (up to 1 wt%) exhibited no toxicity to cardiomyocytes and enhanced cell adhesion and elongation. Through the use of immunohistochemical staining, transmission electron microscopy, and intracellular calcium-transient measurement, the incorporation of CNTs was found to improve cell alignment and assembly remarkably, which led to the formation of engineered cardiac tissues with stronger contraction potential. Importantly, cardiac tissues based on CNT/Col hydrogels were noted to have better functionality. Collectively, the incorporation of CNTs into the Col hydrogels improved cell alignment and the performance of cardiac constructs. Our study suggests that CNT/Col hydrogels offer a promising tissue scaffold for cardiac constructs, and might serve as injectable biomaterials to deliver cell or drug molecules for cardiac regeneration following myocardial infarction in the near future.

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 91 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 20%
Student > Ph. D. Student 15 16%
Student > Bachelor 9 10%
Researcher 8 9%
Student > Doctoral Student 6 7%
Other 8 9%
Unknown 27 30%
Readers by discipline Count As %
Materials Science 11 12%
Engineering 11 12%
Biochemistry, Genetics and Molecular Biology 10 11%
Chemistry 7 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 19 21%
Unknown 28 31%