| Title |
Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
|
|---|---|
| Published in |
International Journal of Nanomedicine, August 2014
|
| DOI | 10.2147/ijn.s65616 |
| Pubmed ID | |
| Authors |
Lionel Gamarra, Larissa Alvarim, Leopoldo Nucci, Javier Mamani, Luciana Marti, Marina Aguiar, Helio Silva, Gisele Silva, Mariana Nucci, Elaine Del Bel |
| Abstract |
The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson's disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 2% |
| Unknown | 58 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 15% |
| Student > Ph. D. Student | 6 | 10% |
| Researcher | 5 | 8% |
| Student > Master | 5 | 8% |
| Student > Postgraduate | 4 | 7% |
| Other | 15 | 25% |
| Unknown | 15 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 25% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Agricultural and Biological Sciences | 3 | 5% |
| Neuroscience | 3 | 5% |
| Psychology | 3 | 5% |
| Other | 13 | 22% |
| Unknown | 16 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2014.
All research outputs
#6,407,124
of 22,763,032 outputs
Outputs from International Journal of Nanomedicine
#683
of 3,806 outputs
Outputs of similar age
#60,810
of 229,520 outputs
Outputs of similar age from International Journal of Nanomedicine
#14
of 60 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,806 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,520 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.