Title |
Progesterone prevents development of neuropathic pain in a rat model: Timing and duration of treatment are critical
|
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Published in |
Journal of Pain Research, April 2011
|
DOI | 10.2147/jpr.s17009 |
Pubmed ID | |
Authors |
Liliane J Dableh, James L Henry |
Abstract |
Progesterone is emerging as an important protective agent against various injuries to the nervous system. Neuroprotective and remyelinating effects have been documented for this neurosteroid, which is synthesized by, and acts on, the central and peripheral nervous systems. Neuropathic pain is a severe, persistent condition that is generally resistant to treatment, and poses major personal, social, and economic burdens. The purpose of this study was to determine if single-dose or repeated progesterone administration would alleviate tactile hypersensitivity in a rat model of neuropathic pain, and to determine if early versus late initiation of treatment has an effect on the outcome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Unknown | 33 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 24% |
Student > Ph. D. Student | 4 | 12% |
Professor | 4 | 12% |
Professor > Associate Professor | 3 | 9% |
Student > Bachelor | 2 | 6% |
Other | 8 | 24% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 32% |
Agricultural and Biological Sciences | 6 | 18% |
Neuroscience | 4 | 12% |
Nursing and Health Professions | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 1 | 3% |
Unknown | 8 | 24% |