| Title |
Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes
|
|---|---|
| Published in |
International Journal of Nanomedicine, September 2014
|
| DOI | 10.2147/ijn.s66050 |
| Pubmed ID | |
| Authors |
J Justin Mulvey, Evan N Feinberg, Simone Alidori, Michael R McDevitt, Daniel A Heller, David A Scheinberg |
| Abstract |
We aimed to create a more robust and more accessible standard for amine-modifying single-walled carbon nanotubes (SWCNTs). A 1,3-cycloaddition was developed using an azomethine ylide, generated by reacting paraformaldehyde and a side-chain-Boc (tert-Butyloxycarbonyl)-protected, lysine-derived alpha-amino acid, H-Lys(Boc)-OH, with purified SWCNT or C60. This cycloaddition and its lysine adduct provides the benefits of dense, covalent modification, ease of purification, commercial availability of reagents, and pH-dependent solubility of the product. Subsequently, SWCNTs functionalized with lysine amine handles were covalently conjugated to a radiometalated chelator, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). The (111)In-labeled construct showed rapid renal clearance in a murine model and a favorable biodistribution, permitting utility in biomedical applications. Functionalized SWCNTs strongly wrapped small interfering RNA (siRNA). In the first disclosed deployment of thermophoresis with carbon nanotubes, the lysine-modified tubes showed a desirable, weak SWCNT-albumin binding constant. Thus, lysine-modified nanotubes are a favorable candidate for medicinal work. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| Unknown | 40 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 32% |
| Student > Bachelor | 5 | 12% |
| Student > Master | 5 | 12% |
| Student > Doctoral Student | 4 | 10% |
| Researcher | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 6 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Engineering | 4 | 10% |
| Agricultural and Biological Sciences | 3 | 7% |
| Other | 8 | 20% |
| Unknown | 8 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2014.
All research outputs
#7,356,550
of 25,374,917 outputs
Outputs from International Journal of Nanomedicine
#814
of 4,122 outputs
Outputs of similar age
#68,271
of 248,673 outputs
Outputs of similar age from International Journal of Nanomedicine
#18
of 52 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,673 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.