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Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

Overview of attention for article published in Drug Design, Development and Therapy, September 2014
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Mentioned by

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1 tweeter

Citations

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4 Dimensions

Readers on

mendeley
11 Mendeley
Title
Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain
Published in
Drug Design, Development and Therapy, September 2014
DOI 10.2147/dddt.s65673
Pubmed ID
Authors

Ping-Hua Sun, Ling-Xing Shan, Bao-Qin Guo, Xin-Jun Xu, Zhi-Qiang Li, Jiazhi Sun, Shu-Feng Zhou, Wei-Min Chen

Abstract

Seventeen acylides bearing an aryl-tetrazolyl alkyl-substituted side chain were synthesized, starting from clarithromycin, via several reactions including hydrolysis, acetylating, esterification, carbamylation, and Michael addition. The structures of all new compounds were confirmed by (1)H nuclear magnetic resonance spectroscopy, (13)C nuclear magnetic resonance spectroscopy, and mass spectrometry. All these synthesized acylides were evaluated for in vitro antimicrobial activities against gram-positive pathogens (Staphylococcus aureus, Staphylococcus epidermidis) and gram-negative pathogens (Pseudomonas aeruginosa, Escherichia coli), using the broth microdilution method. Results showed that compounds 10e, 10f, 10g, 10 h, 10o have good antibacterial activities.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 18%
Other 1 9%
Lecturer 1 9%
Lecturer > Senior Lecturer 1 9%
Student > Bachelor 1 9%
Other 3 27%
Unknown 2 18%
Readers by discipline Count As %
Chemistry 5 45%
Biochemistry, Genetics and Molecular Biology 1 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Medicine and Dentistry 1 9%
Agricultural and Biological Sciences 1 9%
Other 0 0%
Unknown 2 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2014.
All research outputs
#2,294,793
of 4,507,652 outputs
Outputs from Drug Design, Development and Therapy
#189
of 566 outputs
Outputs of similar age
#59,058
of 120,761 outputs
Outputs of similar age from Drug Design, Development and Therapy
#3
of 10 outputs
Altmetric has tracked 4,507,652 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 566 research outputs from this source. They receive a mean Attention Score of 1.9. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,761 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.