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Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide

Overview of attention for article published in International Journal of Nanomedicine, October 2014
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Title
Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
Published in
International Journal of Nanomedicine, October 2014
DOI 10.2147/ijn.s63608
Pubmed ID
Authors

Saifullah Bullo, Palanisamy Arulselvan, Mohamed El Zowalaty, Sharida Sharida Fakurazi, Thomas J. Webster, Benjamin Geilich, Mohd Hussein

Abstract

The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 16%
Student > Master 8 15%
Student > Doctoral Student 6 11%
Professor > Associate Professor 6 11%
Researcher 4 7%
Other 7 13%
Unknown 15 27%
Readers by discipline Count As %
Chemistry 9 16%
Agricultural and Biological Sciences 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Immunology and Microbiology 3 5%
Medicine and Dentistry 3 5%
Other 12 22%
Unknown 19 35%