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Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study

Overview of attention for article published in Clinical, Cosmetic and Investigational Dermatology, December 2013
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Title
Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study
Published in
Clinical, Cosmetic and Investigational Dermatology, December 2013
DOI 10.2147/ccid.s51958
Pubmed ID
Authors

Qian Zheng, Siming Chen, Ying Chen, John Lyga, Russell Wyborksi, Uma Santhanam

Abstract

During aging, the reduction of elastic and collagen fibers in dermis can lead to skin atrophy, fragility, and aged appearance, such as increased facial wrinkling and sagging. Microfibril-associated glycoprotein-1 (MAGP-1) is an extracellular matrix protein critical for elastic fiber assembly. It integrates and stabilizes the microfibril and elastin matrix network that helps the skin to endure mechanical stretch and recoil. However, the observation of MAGP-1 during skin aging and its function in the dermis has not been established. To better understand age-related changes in the dermis, we investigated MAGP-1 during skin aging and photoaging, using a combination of in vitro and in vivo studies. Gene expression by microarray was performed using human skin biopsies from young and aged female donors. In addition, immunofluorescence analysis on the MAGP-1 protein was performed in dermal fibroblast cultures and in human skin biopsies. Specific antibodies against MAGP-1 and fibrillin-1 were used to examine protein expression and extracellular matrix structure in the dermis via biopsies from donors of multiple age groups. A reduction of the MAGP-1 gene and protein levels were observed in human skin with increasing age and photoexposure, indicating a loss of the functional MAGP-1 fiber network and a lack of structural support in the dermis. Loss of MAGP-1 around the hair follicle/pore areas was also observed, suggesting a possible correlation between MAGP-1 loss and enlarged pores in aged skin. Our findings demonstrate that a critical "pre-elasticity" component, MAGP-1, declines with aging and photoaging. Such changes may contribute to age-related loss of dermal integrity and perifollicular structural support, which may lead to skin fragility, sagging, and enlarged pores.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 29%
Student > Ph. D. Student 4 14%
Student > Master 4 14%
Other 2 7%
Professor 2 7%
Other 4 14%
Unknown 4 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 39%
Medicine and Dentistry 5 18%
Engineering 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Unspecified 1 4%
Other 2 7%
Unknown 5 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2014.
All research outputs
#20,242,779
of 22,770,070 outputs
Outputs from Clinical, Cosmetic and Investigational Dermatology
#651
of 711 outputs
Outputs of similar age
#267,691
of 307,271 outputs
Outputs of similar age from Clinical, Cosmetic and Investigational Dermatology
#9
of 9 outputs
Altmetric has tracked 22,770,070 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 711 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,271 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.