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Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers

Overview of attention for article published in International Journal of Nanomedicine, October 2017
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

twitter
3 tweeters

Citations

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36 Dimensions

Readers on

mendeley
51 Mendeley
Title
Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers
Published in
International Journal of Nanomedicine, October 2017
DOI 10.2147/ijn.s145988
Pubmed ID
Authors

Cihui Tian, Sajid Asghar, Yifan Wu, Zhipeng Chen, Xin Jin, Lining Yin, Lin Huang, Qineng Ping, Yanyu Xiao

Abstract

The expression of multiple receptors on intestinal epithelial cells enables an actively targeted carrier to significantly enhance the oral delivery of payloads. Conjugating the receptors' ligands on the surfaces of a particulate-delivery system allows site-specific targeting. Here, we used taurocholic acid (TCA) as a ligand for uptake of nanostructured lipid carriers (NLCs) mediated by a bile-acid transporter to improve oral bioavailability of curcumin (Cur). First, synthesis of TCA-polyethylene glycol 100-monostearate (S100-TCA) was carried out. Then, the physical and chemical properties of S100-TCA-modified Cur-loaded NLCs (Cur-TCA NLCs) with varying levels of S100-TCA modifications were investigated. Small particle size (<150 nm), high drug encapsulation (>90%), drug loading (about 3%), negative ζ-potential (-7 to -3 mV), and sustained release were obtained. In situ intestinal perfusion studies demonstrated improved absorption rate and permeability coefficient of Cur-TCA NLCs. Depending on the degree of modification, Cur-TCA NLCs displayed about a five- to 15-fold higher area under the curve in rats after oral administration than unmodified Cur NLCs, which established that the addition of S100-TCA to the NLCs boosted absorption of Cur. Further investigations of TCA NLCs might reveal a bright future for effective oral delivery of poorly bioavailable drugs.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 22%
Student > Master 7 14%
Student > Ph. D. Student 6 12%
Researcher 4 8%
Student > Postgraduate 2 4%
Other 5 10%
Unknown 16 31%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 9 18%
Chemistry 6 12%
Biochemistry, Genetics and Molecular Biology 4 8%
Medicine and Dentistry 4 8%
Nursing and Health Professions 2 4%
Other 6 12%
Unknown 20 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2017.
All research outputs
#7,294,246
of 12,151,889 outputs
Outputs from International Journal of Nanomedicine
#1,055
of 2,392 outputs
Outputs of similar age
#169,800
of 331,734 outputs
Outputs of similar age from International Journal of Nanomedicine
#31
of 119 outputs
Altmetric has tracked 12,151,889 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,392 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,734 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.