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Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies

Overview of attention for article published in Clinical Interventions in Aging, October 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
6 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
54 Dimensions

Readers on

mendeley
69 Mendeley
Title
Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
Published in
Clinical Interventions in Aging, October 2017
DOI 10.2147/cia.s138002
Pubmed ID
Authors

Carla Caffarelli, Andrea Montagnani, Ranuccio Nuti, Stefano Gonnelli

Abstract

Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of choice for the prevention and treatment of osteoporosis and related fractures. Data from several publications have suggested that BPs may also be effective in reducing the atherosclerotic process and vascular calcification, but the results of these studies are contrasting. This review aimed to allow a better understanding of the relationships between BPs and atherosclerosis in humans. Electronic databases of Pubmed-Medline, Cochrane Library and SCOPUS from inception to June 30, 2016 were searched. The full texts of the articles potentially eligible were carefully assessed and reviewed. Finally, 20 studies were found to be eligible and were included in the systematic review. All included studies were published between 2000 and 2014. In several studies, etidronate limited the progression of aortic and coronary calcification in hemodialysis patients, whereas the nitrogen-containing-BPs given orally did not significantly reduce vascular calcifications in patients with chronic kidney disease, kidney trasplant or in those with osteoporosis. Nitrogen-containing-BPs present favorable effects both on vessel wall thickness and on arterial elasticity due to both a reduction in serum lipids and the interaction of BPs with the bone tissue, with the consequent release of bone turnover markers and cytokines into the bloodstream. To sum up, the BPs seem to have the potential of influencing atherosclerosis and calcium homeostasis at the level of vascular walls with several possible mechanisms which may differ according to the type, potency, dosage and administration route of BPs. Additional studies are needed to specifically address the mechanism by which BP use could influence cardiovascular morbidity and mortality.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 20%
Researcher 9 13%
Student > Master 7 10%
Other 5 7%
Student > Bachelor 3 4%
Other 11 16%
Unknown 20 29%
Readers by discipline Count As %
Medicine and Dentistry 19 28%
Pharmacology, Toxicology and Pharmaceutical Science 6 9%
Biochemistry, Genetics and Molecular Biology 6 9%
Agricultural and Biological Sciences 5 7%
Environmental Science 1 1%
Other 7 10%
Unknown 25 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2018.
All research outputs
#1,375,892
of 19,791,698 outputs
Outputs from Clinical Interventions in Aging
#153
of 1,702 outputs
Outputs of similar age
#42,657
of 434,519 outputs
Outputs of similar age from Clinical Interventions in Aging
#6
of 66 outputs
Altmetric has tracked 19,791,698 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,702 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 434,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.