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Korsakoff’s syndrome: a critical review

Overview of attention for article published in Neuropsychiatric Disease and Treatment, November 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

twitter
6 tweeters
wikipedia
3 Wikipedia pages
q&a
1 Q&A thread

Citations

dimensions_citation
135 Dimensions

Readers on

mendeley
368 Mendeley
Title
Korsakoff’s syndrome: a critical review
Published in
Neuropsychiatric Disease and Treatment, November 2017
DOI 10.2147/ndt.s130078
Pubmed ID
Authors

Nicolaas Arts, Serge Walvoort, Roy Kessels

Abstract

In this review, we present a survey on Korsakoff's syndrome (KS), a residual syndrome in patients who suffered from a Wernicke encephalopathy (WE) that is predominantly characterized by global amnesia, and in more severe cases also by cognitive and behavioral dysfunction. We describe the history of KS and its definition, its epidemiology, and the lack of consensus criteria for its diagnosis. The cognitive and behavioral symptoms of KS, which include anterograde and retrograde amnesia, executive dysfunction, confabulation, apathy, as well as affective and social-cognitive impairments, are discussed. Moreover, recent insights into the underlying neurocognitive mechanisms of these symptoms are presented. In addition, the evidence so far on the etiology of KS is examined, highlighting the role of thiamine and alcohol and discussing the continuity hypothesis. Furthermore, the neuropathology of KS is reviewed, focusing on abnormalities in the diencephalon, including the mammillary bodies and thalamic nuclei. Pharmacological treatment options and nonpharmacological interventions, such as those based on cognitive rehabilitation, are discussed. Our review shows that thiamine deficiency (TD) is a crucial factor in the etiology of KS. Although alcohol abuse is by far the most important context in which TD occurs, there is no convincing evidence for an essential contribution of ethanol neurotoxicity (EN) to the development of WE or to the progression of WE to KS. Future research on the postmortem histopathological analysis of brain tissues of KS patients is crucial for the advancement of our knowledge of KS, especially for associating its symptoms with lesions in various thalamic nuclei. A necessary requirement for the advancement of studies on KS is the broad acceptance of a comprehensive definition and definite diagnostic criteria. Therefore, in this review, we propose such a definition of KS and draft outlines for prospective diagnostic criteria.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 368 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 368 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 76 21%
Student > Master 33 9%
Other 30 8%
Researcher 29 8%
Student > Postgraduate 26 7%
Other 66 18%
Unknown 108 29%
Readers by discipline Count As %
Medicine and Dentistry 81 22%
Psychology 78 21%
Neuroscience 33 9%
Nursing and Health Professions 9 2%
Biochemistry, Genetics and Molecular Biology 9 2%
Other 33 9%
Unknown 125 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2021.
All research outputs
#3,515,329
of 22,530,935 outputs
Outputs from Neuropsychiatric Disease and Treatment
#486
of 2,960 outputs
Outputs of similar age
#70,884
of 344,214 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#9
of 60 outputs
Altmetric has tracked 22,530,935 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,960 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,214 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.