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Profile of aripiprazole in the treatment of bipolar disorder in children and adolescents

Overview of attention for article published in Adolescent Health, Medicine and Therapeutics, November 2014
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Title
Profile of aripiprazole in the treatment of bipolar disorder in children and adolescents
Published in
Adolescent Health, Medicine and Therapeutics, November 2014
DOI 10.2147/ahmt.s50015
Pubmed ID
Authors

Eiji Kirino

Abstract

Bipolar disorder is a pernicious illness. Compared with the later-onset form, early onset bipolar disorder is associated with worse psychosocial outcomes, and is characterized by rapid cycling and increased risks of substance abuse and suicide attempts. Controlling mood episodes and preventing relapse in this group of pediatric patients requires careful treatment. Here, we review the effectiveness of aripiprazole for bipolar disorder in children and adolescents, with discussion of this drug's unique pharmacological profile and various clinical study outcomes. Aripiprazole acts as a serotonin 5-HT2A receptor antagonist, as well as a partial agonist of the serotonin 5-HT1A and dopamine D2 receptors. It can be safely used in children and adolescents, as it is highly tolerated and shows lower rates of the side effects typically observed with other antipsychotic drugs, including sedation, weight gain, hyperprolactinemia, and extrapyramidal syndrome. The presently reviewed randomized controlled trials (RCTs) and non-RCTs generally reported aripiprazole to be effective and well-tolerated in children and adolescents with bipolar disorder. However, due to the limited number of RCTs, the present conclusions must be evaluated cautiously. Furthermore, aripiprazole cannot yet be considered a preferred treatment for children and adolescents with bipolar disorder, as there is not yet evidence that aripiprazole shows greater efficacy compared to other second-generation antipsychotics. Additional data are needed from future head-to-head comparison studies.

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Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 4%
Brazil 1 4%
Unknown 23 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 20%
Student > Postgraduate 5 20%
Student > Doctoral Student 4 16%
Student > Bachelor 4 16%
Student > Ph. D. Student 3 12%
Other 4 16%
Readers by discipline Count As %
Medicine and Dentistry 9 36%
Pharmacology, Toxicology and Pharmaceutical Science 3 12%
Unspecified 3 12%
Agricultural and Biological Sciences 2 8%
Neuroscience 2 8%
Other 6 24%