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Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

Overview of attention for article published in International Journal of Nanomedicine, April 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
2 news outlets
twitter
1 tweeter

Citations

dimensions_citation
67 Dimensions

Readers on

mendeley
93 Mendeley
Title
Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy
Published in
International Journal of Nanomedicine, April 2017
DOI 10.2147/ijn.s131786
Pubmed ID
Authors

Wei Jiang Goh, Choon Keong Lee, Shui Zou, Esther Woon, Bertrand Czarny, Giorgia Pastorin

Abstract

Cell-derived nanovesicles (CDNs) are an emerging class of biological drug delivery systems (DDS) that retain the characteristics of the cells they were derived from, without the need for further surface functionalization. CDNs are also biocompatible, being derived from natural sources and also take advantage of the enhanced permeability and retention effect due to their nanodimensions. Furthermore, CDNs derived from monocytes were shown to have an in vivo targeting effect, accumulating at the tumor site in a previous study conducted in a mouse tumor model. Here, we report a systematic approach pertaining to various loading methods of the chemotherapeutic drug doxorubicin into our CDNs and examine the differential cellular uptake of drug-loaded CDNs in cancerous (HeLa) and healthy (HEK293) cell lines. Lastly, we proved that the addition of doxorubicin-loaded CDNs to the HeLa and HEK293 co-cultures showed a clear discrimination toward cancer cells at the cellular level. Our results further reinforce the intriguing potential of CDNs as an alternative targeted strategy for anticancer therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 93 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 27%
Student > Master 17 18%
Researcher 13 14%
Student > Bachelor 5 5%
Other 3 3%
Other 8 9%
Unknown 22 24%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 23 25%
Biochemistry, Genetics and Molecular Biology 18 19%
Engineering 6 6%
Agricultural and Biological Sciences 5 5%
Medicine and Dentistry 5 5%
Other 12 13%
Unknown 24 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2020.
All research outputs
#1,469,733
of 18,523,374 outputs
Outputs from International Journal of Nanomedicine
#56
of 3,314 outputs
Outputs of similar age
#47,199
of 424,463 outputs
Outputs of similar age from International Journal of Nanomedicine
#3
of 109 outputs
Altmetric has tracked 18,523,374 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,314 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,463 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.