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Antibacterial properties of PEKK for orthopedic applications

Overview of attention for article published in International Journal of Nanomedicine, September 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 3,746)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
11 news outlets
patent
3 patents
facebook
1 Facebook page

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
63 Mendeley
Title
Antibacterial properties of PEKK for orthopedic applications
Published in
International Journal of Nanomedicine, September 2017
DOI 10.2147/ijn.s134983
Pubmed ID
Authors

Mian Wang, Garima Bhardwaj, Thomas Webster

Abstract

Orthopedic implant infections have been steadily increasing while, at the same time, antibiotics developed to kill such bacteria have proven less and less effective with every passing day. It is clear that new approaches that do not rely on the use of antibiotics are needed to decrease medical device infections. Inspired by cicada wing surface topographical features, nanostructured surfaces represent a new approach for imposing antibacterial properties to biomaterials without using drugs. Moreover, new chemistries with altered surface energetics may decrease bacterial attachment and growth. In this study, a nanostructured surface was fabricated on poly-ether-ketone-ketone (PEKK), a new orthopedic implant chemistry, comprised of nanopillars with random interpillar spacing. Specifically, after 5 days, when compared to the orthopedic industry standard poly-ether-ether-ketone (PEEK), more than 37% less Staphylococcus epidermidis were found on the PEKK surface. Pseudomonas aeruginosa attachment and growth also decreased 28% after one day of culture, with around a 50% decrease after 5 days of culture when compared to PEEK. Such decreases in bacteria function were achieved without using antibiotics. In this manner, this study demonstrated for the first time, the promise that nanostructured PEKK has for numerous anti-infection orthopedic implant applications.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 19%
Student > Master 12 19%
Researcher 11 17%
Student > Doctoral Student 5 8%
Student > Bachelor 4 6%
Other 7 11%
Unknown 12 19%
Readers by discipline Count As %
Engineering 13 21%
Medicine and Dentistry 11 17%
Materials Science 5 8%
Agricultural and Biological Sciences 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 10 16%
Unknown 19 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 83. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2022.
All research outputs
#423,069
of 22,444,133 outputs
Outputs from International Journal of Nanomedicine
#20
of 3,746 outputs
Outputs of similar age
#9,902
of 292,608 outputs
Outputs of similar age from International Journal of Nanomedicine
#1
of 55 outputs
Altmetric has tracked 22,444,133 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,746 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,608 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.