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Endothelial dysfunction assessment by flow-mediated dilation in a high-altitude population

Overview of attention for article published in Vascular Health and Risk Management, November 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
2 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
48 Mendeley
Title
Endothelial dysfunction assessment by flow-mediated dilation in a high-altitude population
Published in
Vascular Health and Risk Management, November 2017
DOI 10.2147/vhrm.s151886
Pubmed ID
Authors

Walter Calderón-Gerstein, Antonio López-Peña, Raúl Macha-Ramírez, Astrid Bruno-Huamán, Roxana Espejo-Ramos, Stephany Vílchez-Bravo, Maria Ramírez-Breña, Milagros Damián-Mucha, Adriana Matos-Mucha

Abstract

Endothelial function at high altitude has been measured only in populations that are genetically adapted to chronic hypoxia. The objective of this study was to evaluate endothelial dysfunction (ED) in a nongenetically adapted high-altitude population of the Andes mountains, in Huancayo, Peru (3,250 meters above sea level). Participants included 61 patients: 28 cases and 33 controls. The cases were subjects with hypertension, diabetes mellitus, obesity, or a history of stroke or coronary artery disease. Flow-mediated vasodilation (FMD) of the brachial artery was measured in the supine position, at noon, after 5 minutes of resting. The brachial artery was identified above the elbow. Its basal diameter was measured during diastole, and FMD was tested after 5 minutes of forearm ischemia. Intima-media complex in the right carotid artery was also determined. An increase in the artery's baseline diameter <10% indicated a positive test. Endothelium-independent vasodilation was evaluated with sublingual nitrate administration. The intima-media complex in the right carotid artery was also measured. 100% of diabetics had ED; ED was also found in 68.8% of obese individuals, 55% of hypertensive patients, and 46.5% of controls. Age, height, body mass index, and waist diameter were higher in the cases as compared with the controls. A total of 57.9% (n=11) of the cases and 45.2% (n=19) of the controls presented ED. Patients without ED had a mean increase in brachial artery diameter of 23.16%, while in those with ED it was only 3.84%. Individuals with diabetes or hypertension had a greater thickness of the carotid artery intima media layer (1.092 versus 0.664 cm) (p=0.037). A positive test for ED was associated with a greater basal diameter of the brachial artery (4.66±0.62 versus 4.23±0.59 cm) (p=0.02). A total of 7 patients presented paradoxical response, developing posthyperemia vasoconstriction. The proportion of ED was high among controls and among patients with risk factors. Controls showed better FMD profiles than subjects studied in Tibet and the Himalayas.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 27%
Student > Master 5 10%
Researcher 4 8%
Student > Postgraduate 4 8%
Student > Ph. D. Student 4 8%
Other 5 10%
Unknown 13 27%
Readers by discipline Count As %
Medicine and Dentistry 15 31%
Agricultural and Biological Sciences 5 10%
Engineering 4 8%
Biochemistry, Genetics and Molecular Biology 3 6%
Sports and Recreations 3 6%
Other 3 6%
Unknown 15 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2018.
All research outputs
#5,951,132
of 21,744,520 outputs
Outputs from Vascular Health and Risk Management
#206
of 729 outputs
Outputs of similar age
#135,155
of 446,468 outputs
Outputs of similar age from Vascular Health and Risk Management
#4
of 9 outputs
Altmetric has tracked 21,744,520 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 729 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,468 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.