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Fish oil supplementation associated with decreased cellular degeneration and increased cellular proliferation 6 weeks after middle cerebral artery occlusion in the rat

Overview of attention for article published in Neuropsychiatric Disease and Treatment, January 2015
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Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

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4 Dimensions

Readers on

mendeley
30 Mendeley
Title
Fish oil supplementation associated with decreased cellular degeneration and increased cellular proliferation 6 weeks after middle cerebral artery occlusion in the rat
Published in
Neuropsychiatric Disease and Treatment, January 2015
DOI 10.2147/ndt.s72925
Pubmed ID
Authors

Michaela Pascoe, David Howells, Sheila Crewther, David Crewther, Leeanne Carey

Abstract

Anti-inflammatory long-chain omega-3 polyunsaturated fatty acids (n-3-LC-PUFAs) are both neuroprotective and have antidepressive effects. However the influence of dietary supplemented n-3-LC-PUFAs on inflammation-related cell death and proliferation after middle cerebral artery occlusion (MCAo)-induced stroke is unknown. We have previously demonstrated that anxiety-like and hyperactive locomotor behaviors are reduced in n-3-LC-PUFA-fed MCAo animals. Thus in the present study, male hooded Wistar rats were exposed to MCAo or sham surgeries and examined behaviorally 6 weeks later, prior to euthanasia and examination of lesion size, cell death and proliferation in the dentate gyrus, cornu ammonis region of the hippocampus of the ipsilesional hemispheres, and the thalamus of the ipsilesional and contralesional hemispheres. Markers of cell genesis and cell degeneration in the hippocampus or thalamus of the ipsilesional hemisphere did not differ between surgery and diet groups 6 weeks post MCAo. Dietary supplementation with n-3-LC-PUFA decreased cell degeneration and increased cell proliferation in the thalamic region of the contralesional hemisphere. MCAo-associated cell degeneration in the hippocampus and thalamus positively correlated with anxiety-like and hyperactive locomotor behaviors previously reported in these animals. These results suggest that anti-inflammatory n-3-LC-PUFA supplementation appears to have cellular protective effects after MCAo in the rat, which may affect behavioral outcomes.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 20%
Student > Ph. D. Student 4 13%
Student > Master 4 13%
Student > Postgraduate 3 10%
Researcher 3 10%
Other 4 13%
Unknown 6 20%
Readers by discipline Count As %
Medicine and Dentistry 8 27%
Neuroscience 4 13%
Biochemistry, Genetics and Molecular Biology 3 10%
Psychology 2 7%
Agricultural and Biological Sciences 2 7%
Other 3 10%
Unknown 8 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2015.
All research outputs
#7,548,199
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,211
of 2,120 outputs
Outputs of similar age
#127,967
of 270,914 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#29
of 69 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,914 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.