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 α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies

Overview of attention for article published in International Journal of Nanomedicine, June 2012
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

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1 tweeter

Citations

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17 Dimensions

Readers on

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16 Mendeley
Title
 α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies
Published in
International Journal of Nanomedicine, June 2012
DOI 10.2147/ijn.s31373
Pubmed ID
Authors

Sergey Shityakov

Abstract

This paper attempts to predict and emphasize molecular interactions of dopamine, levodopa, and their derivatives (Dopimid compounds) containing 2-phenyl-imidazopyridine moiety with the α-cyclodextrin dimer in order to assess and improve drug delivery to the central nervous system. The molecular docking method is used to determine the energetic profiles, hydrogen bond formation, and hydrophobic effect of 14 host-guest complexes. The results show that the "chemical branching" represented by additional ethyl-acetate residue is energetically unfavorable and promotes a conformational shift due to the high root mean square deviation levels. This phenomenon is characterized by a low number of H-bonds and a significant decrease of the host-guest hydrophobic potential surface. Finally, the overall docking procedure presents a powerful rationale for screening and analyzing various sets of promising drug-like chemical compounds in the fields of supramolecular chemistry, molecular sensing, synthetic receptors, and nanobiotechnology.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 6%
Turkey 1 6%
Unknown 14 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 38%
Researcher 4 25%
Student > Bachelor 3 19%
Professor > Associate Professor 2 13%
Student > Doctoral Student 1 6%
Other 0 0%
Readers by discipline Count As %
Chemistry 7 44%
Engineering 2 13%
Agricultural and Biological Sciences 2 13%
Computer Science 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2015.
All research outputs
#3,897,301
of 7,546,288 outputs
Outputs from International Journal of Nanomedicine
#972
of 1,709 outputs
Outputs of similar age
#118,291
of 235,899 outputs
Outputs of similar age from International Journal of Nanomedicine
#16
of 45 outputs
Altmetric has tracked 7,546,288 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,709 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,899 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.