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Design and immunological evaluation of anti-CD205-tailored PLGA-based nanoparticulate cancer vaccine

Overview of attention for article published in International Journal of Nanomedicine, January 2018
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

twitter
4 tweeters

Citations

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15 Dimensions

Readers on

mendeley
28 Mendeley
Title
Design and immunological evaluation of anti-CD205-tailored PLGA-based nanoparticulate cancer vaccine
Published in
International Journal of Nanomedicine, January 2018
DOI 10.2147/ijn.s144266
Pubmed ID
Authors

Sheikh Tasnim Jahan, Sams MA Sadat, Azita Haddadi

Abstract

The aim of this research was to develop a targeted antigen-adjuvant assembled delivery system that will enable dendritic cells (DCs) to efficiently mature to recognize antigens released from tumor cells. It is important to target the DCs with greater efficiency to prime T cell immune responses. In brief, model antigen, ovalbumin (OV), and monophosphoryl lipid A adjuvant were encapsulated within the nanoparticle (NP) by double emulsification solvent evaporation method. Targeted NPs were obtained through ligand incorporation via physical adsorption or chemical conjugation process. Intracellular uptake of the NPs and the maturation of DCs were evaluated with flow cytometry. Remarkably, the developed delivery system had suitable physicochemical properties, such as particle size, surface charge, OV encapsulation efficiency, biphasic OV release pattern, and safety profile. The ligand modified formulations had higher targeting efficiency than the non-tailored NPs. This was also evident when the targeted formulations expressed comparatively higher fold increase in surface activation markers such as CD40, CD86, and major histocompatibility complex class II molecules. The maturation of DCs was further confirmed through secretion of extracellular cytokines compared to control cells in the DC microenvironment. Physicochemical characterization of NPs was performed based on the polymer end groups, their viscosities, and ligand-NP bonding type. In conclusion, the DC stimulatory response was integrated to develop a relationship between the NP structure and desired immune response. Therefore, the present study narrates a comparative evaluation of some selected parameters to choose a suitable formulation useful for in vivo cancer immunotherapy.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 25%
Researcher 5 18%
Student > Bachelor 5 18%
Student > Master 2 7%
Other 2 7%
Other 3 11%
Unknown 4 14%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 21%
Medicine and Dentistry 3 11%
Immunology and Microbiology 3 11%
Biochemistry, Genetics and Molecular Biology 3 11%
Chemistry 2 7%
Other 4 14%
Unknown 7 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2018.
All research outputs
#9,460,148
of 16,099,285 outputs
Outputs from International Journal of Nanomedicine
#1,125
of 3,008 outputs
Outputs of similar age
#182,188
of 369,377 outputs
Outputs of similar age from International Journal of Nanomedicine
#19
of 95 outputs
Altmetric has tracked 16,099,285 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,008 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,377 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.