| Title |
The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials
|
|---|---|
| Published in |
Drug Design, Development and Therapy, January 2018
|
| DOI | 10.2147/dddt.s155110 |
| Pubmed ID | |
| Authors |
Tzu-Lin Yeh, Pei-Ching Shih, Shu-Jung Liu, Chao-Hsu Lin, Jui-Ming Liu, Wei-Te Lei, Chien-Yu Lin |
| Abstract |
Influenza infection is a common disease with a huge disease burden. Influenza vaccination has been widely used, but concerns regarding vaccine efficacy exist, especially in the elderly. Probiotics are live microorganisms with immunomodulatory effects and may enhance the immune responses to influenza vaccination. We conducted a systematic review and meta-analysis to determine the influence of prebiotics/probiotics/synbiotics supplementation on vaccine responses to influenza vaccination. Studies were systematically identified from electronic databases up to July 2017. Information regarding study population, influenza vaccination, components of supplements, and immune responses were extracted and analyzed. Twelve studies, investigating a total of 688 participants, were included in this review. Patients with prebiotics/probiotics supplements were found to have higher influenza hemagglutination inhibition antibody titers after vaccination (for A/H1N1, 42.89 vs 35.76, mean difference =7.14, 95% CI =2.73, 11.55, P=0.002; for A/H3N2, 105.4 vs 88.25, mean difference =17.19, 95% CI =3.39, 30.99, P=0.01; for B strain, 34.87 vs 30.73, mean difference =4.17, 95% CI =0.37, 7.96, P=0.03). Supplementation with prebiotics or probiotics may enhance the influenza hemagglutination inhibition antibody titers in all A/H1N1, A/H3N2, and B strains (20%, 19.5%, and 13.6% increases, respectively). Concomitant prebiotics or probiotics supplementation with influenza vaccination may hold great promise for improving vaccine efficacy. However, high heterogeneity was observed and further studies are warranted. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 18% |
| Canada | 2 | 7% |
| United Kingdom | 2 | 7% |
| New Zealand | 1 | 4% |
| Japan | 1 | 4% |
| Brazil | 1 | 4% |
| Georgia | 1 | 4% |
| India | 1 | 4% |
| Unknown | 14 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 79% |
| Practitioners (doctors, other healthcare professionals) | 4 | 14% |
| Scientists | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 118 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 19% |
| Student > Bachelor | 13 | 11% |
| Other | 12 | 10% |
| Student > Master | 8 | 7% |
| Student > Ph. D. Student | 6 | 5% |
| Other | 20 | 17% |
| Unknown | 37 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 23% |
| Agricultural and Biological Sciences | 13 | 11% |
| Nursing and Health Professions | 9 | 8% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Immunology and Microbiology | 5 | 4% |
| Other | 13 | 11% |
| Unknown | 44 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2023.
All research outputs
#2,004,536
of 25,382,440 outputs
Outputs from Drug Design, Development and Therapy
#96
of 2,268 outputs
Outputs of similar age
#44,679
of 449,550 outputs
Outputs of similar age from Drug Design, Development and Therapy
#4
of 38 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,268 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.