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Hyperprolactinemia in Thai children and adolescents with autism spectrum disorder treated with risperidone

Overview of attention for article published in Neuropsychiatric Disease and Treatment, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

blogs
1 blog
twitter
9 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
36 Mendeley
Title
Hyperprolactinemia in Thai children and adolescents with autism spectrum disorder treated with risperidone
Published in
Neuropsychiatric Disease and Treatment, January 2015
DOI 10.2147/ndt.s76276
Pubmed ID
Authors

Chonlaphat Sukasem, Yaowaluck Hongkaew, Nattawat Ngamsamut, Apichaya Puangpetch, Natchaya Vanwong, Pornpen Srisawasdi, Montri Chamnanphon, Bhunada Chamkrachchangpada, Teerarat Tan-kam, Apichaya Puangpetch

Abstract

Hyperprolactinemia is a common adverse effect observed in children with autism spectrum disorder (ASD) during pharmacotherapy with risperidone. The main aim of this study was to investigate important clinical factors influencing the prolactin response in risperidone-treated Thai ASD. A total of 147 children and adolescents (127 males and 20 females) aged 3-19 years with ASD received risperidone treatment (0.10-6.00 mg/day) for up to 158 weeks. Prolactin levels were measured by chemiluminescence immunoassay. The clinical data of patients collected from medical records - age, weight, height, body mass index, dose of risperidone, duration of treatment, and drug-use pattern - were recorded. Hyperprolactinemia was observed in 66 of 147 (44.90%) subjects. Median prolactin level at the high doses (24.00, interquartile range [IQR] 14.30-29.20) of risperidone was significantly found to be higher than at the recommended (16.20, IQR 10.65-22.30) and low (11.70, IQR 7.51-16.50) doses of risperidone. There was no relationship between prolactin levels and duration of risperidone treatment. Dose-dependence is identified as a main factor associated with hyperprolactinemia in Thai children and adolescents with ASD treated with risperidone. This study suggests that risperidone treatment causes prolactin elevations and the effects of risperidone on prolactin are probably dose-related in pediatric patients.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Researcher 4 11%
Student > Postgraduate 3 8%
Student > Bachelor 3 8%
Professor 2 6%
Other 10 28%
Unknown 7 19%
Readers by discipline Count As %
Medicine and Dentistry 12 33%
Psychology 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Nursing and Health Professions 3 8%
Immunology and Microbiology 1 3%
Other 4 11%
Unknown 9 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2018.
All research outputs
#1,139,534
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#172
of 2,120 outputs
Outputs of similar age
#28,975
of 271,047 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#11
of 68 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,047 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.