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The impact of liposomal linolenic acid on gastrointestinal microbiota in mice

Overview of attention for article published in International Journal of Nanomedicine, March 2018
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1 tweeter
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1 Facebook page

Citations

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8 Dimensions

Readers on

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32 Mendeley
Title
The impact of liposomal linolenic acid on gastrointestinal microbiota in mice
Published in
International Journal of Nanomedicine, March 2018
DOI 10.2147/ijn.s151825
Pubmed ID
Authors

Xuan-xuan Li, Si Shi, Lan Rong, Mei-qing Feng, Liang Zhong

Abstract

The prevalence ofHelicobacter pylorihas long been a global health issue. Triple therapy, being the first-line treatment, has caused dysbiosis of the gastrointestinal tract that led to various complications. A novel nanomedicine - liposomal linolenic acid (LipoLLA) - has been proven to have great potential in eradicatingH. pylori. However, the possible side effects of LipoLLA due to alteration of the gastrointestinal microbiota remain unknown. This study focused on the impact of LipoLLA on gastrointestinal microbiota in mice in comparison with triple therapy in order to assess the safety profile. Mice were divided into five groups: blank control group;H. pyloricontrol group; triple therapy group; low-dose LipoLLA group (25 mg/kg); and high-dose LipoLLA group (50 mg/kg). Fecal samples were collected before and after the intake of corresponding formulas. Gastric tissues were obtained after mice dissection. These samples were analyzed with high-throughput sequencing. The analysis revealed that LipoLLA resulted in minor gut microbiota alteration at different levels. The altered proportions in the high-dose group were higher than that of the low-dose group. On the other hand, the triple therapy group showed dramatic shifts in the major community composition. It displayed a notable boost in the relative abundance ofProteobacteriaandFirmicutesalong with a decrease in that ofVerrucomicrobiaandBacteroidetes. All of them belonged to the major phyla in the microbiome. Triple therapy also led to the growth of the familyEnterobacteriaceae,Enterococcaceae, andClostridiaceae_1that may be associated with clinical illnesses. Gastric microbiota analysis reached similar conclusions. Our findings indicated that LipoLLA causes minor gastrointestinal microbiota alterations while the triple therapy triggered dramatic changes. Thus, LipoLLA is not only promising but also a safe therapeutic medication to eradicateH. pyloriinfection.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 31%
Student > Master 4 13%
Other 3 9%
Student > Ph. D. Student 3 9%
Student > Postgraduate 2 6%
Other 5 16%
Unknown 5 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 16%
Agricultural and Biological Sciences 5 16%
Immunology and Microbiology 4 13%
Engineering 3 9%
Medicine and Dentistry 3 9%
Other 5 16%
Unknown 7 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#9,755,095
of 12,728,337 outputs
Outputs from International Journal of Nanomedicine
#1,822
of 2,493 outputs
Outputs of similar age
#187,143
of 272,789 outputs
Outputs of similar age from International Journal of Nanomedicine
#27
of 48 outputs
Altmetric has tracked 12,728,337 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,493 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,789 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.