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Analysis of the association of MIR124-1 and its target gene RGS4 polymorphisms with major depressive disorder and antidepressant response

Overview of attention for article published in Neuropsychiatric Disease and Treatment, March 2018
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Title
Analysis of the association of <em>MIR124-1</em> and its target gene <em>RGS4</em> polymorphisms with major depressive disorder and antidepressant response
Published in
Neuropsychiatric Disease and Treatment, March 2018
DOI 10.2147/ndt.s155076
Pubmed ID
Authors

Duan Zeng, Shen He, Shunying Yu, Guanjun Li, Changlin Ma, Yi Wen, Yifeng Shen, Yimin Yu, Huafang Li

Abstract

Increasing evidence has indicated that dysfunction of miR-124 and target gene regulator of G protein signaling 4 (RGS4) may be involved in the etiology and treatment of major depressive disorder (MDD). However, the molecular mechanisms are not fully understood. This study aimed to investigate whether common genetic variations in these two genes are associated with MDD and therapeutic response to antidepressants in the Chinese population. Three polymorphisms including rs531564 (a functional single-nucleotide polymorphism [SNP] in MIR124-1), rs10759 (a microRNA-binding site SNP in RGS4), and rs951436 (a promoter SNP in RGS4) were genotyped in 225 Chinese MDD patients and 436 controls. Among the MDD patients, 147 accepted antidepressant treatment for 8 weeks with therapeutic evaluation at baseline, week 2, week 4, week 6, and week 8 using the 17-item Hamilton Rating Scale for Depression. Multifactor dimensionality reduction (MDR) was used to identify gene-gene interactions. No significant association with MDD was discovered in single-SNP analyses. However, by MDR analysis, the three-locus model of gene-gene interaction was the best for predicting MDD risk. In pharmacogenetic study, a significant association was found in genotypic frequencies of rs951436 between the remitter and non-remitter groups (p=0.026, correction p=0.078). For further analysis, the rs951436 heterozygote carriers had threefold probabilities of achieving clinical complete remission (odds ratio =3.00, 95% confidence interval =1.33-6.76, p=0.007, correction p=0.021) as compared with rs951436 homozygotes (AA+CC) after 8 weeks of treatment. An interaction effect of MIR124-1 and RGS4 polymorphisms may play a more important role than individual factors for MDD development. Moreover, RGS4 gene polymorphisms may be associated with antidepressant response among the Han population.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 25%
Student > Ph. D. Student 3 13%
Student > Doctoral Student 3 13%
Other 2 8%
Lecturer 1 4%
Other 2 8%
Unknown 7 29%
Readers by discipline Count As %
Neuroscience 4 17%
Medicine and Dentistry 4 17%
Psychology 4 17%
Biochemistry, Genetics and Molecular Biology 2 8%
Agricultural and Biological Sciences 1 4%
Other 3 13%
Unknown 6 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2018.
All research outputs
#11,520,223
of 14,537,474 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,843
of 2,487 outputs
Outputs of similar age
#208,119
of 277,115 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#56
of 80 outputs
Altmetric has tracked 14,537,474 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,487 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.