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Factors related to improvement of symptoms, function, and caregiver burden in Chinese patients with schizophrenia after switching to paliperidone palmitate once-monthly from oral antipsychotics

Overview of attention for article published in Neuropsychiatric Disease and Treatment, March 2018
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Mentioned by

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1 tweeter
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1 Facebook page

Citations

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3 Dimensions

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20 Mendeley
Title
Factors related to improvement of symptoms, function, and caregiver burden in Chinese patients with schizophrenia after switching to paliperidone palmitate once-monthly from oral antipsychotics
Published in
Neuropsychiatric Disease and Treatment, March 2018
DOI 10.2147/ndt.s158353
Pubmed ID
Authors

Nan Li, Yu Feng, Huafei Lu, Shang Li Cai, Jianmin Zhuo, Tianmei Si, Lili Zhang

Abstract

Paliperidone palmitate once-monthly (PP1M) demonstrated symptomatic and functional remission in patients with schizophrenia. This post hoc analysis aimed to identify factors associated with improved clinical outcomes in patients switching to PP1M (75-150 mg eq.). The improved patient outcomes were observed as Positive and Negative Symptom Scale (PANSS, symptoms) score <70:66.7% (407/610), Personal and Social Performance (PSP, function) score >70:34.3% (199/581), and Involvement Evaluation Questionnaire (IEQ, caregiver burden) reduction ≥6:50.2% (270/538). Independent variables including demographics, disease duration, employment status, and clinical scores were screened individually using a univariate analysis and subsequently, variables (cutoffp<0.15) were analyzed using a multivariate regression analysis for association with better clinical outcomes at week 13. The factors significantly associated with favorable clinical outcomes were reduction in PANSS at week 5 (odds ratio [OR]=1.14, 95% CI=1.11-1.17) with symptom reduction; baseline PSP total score (OR=1.07, 95% CI=1.05-1.10), PSP change at week 5 (OR=1.07, 95% CI=1.05-1.10), PANSS reduction at week 5 (OR=1.06, 95% CI=1.03-1.08) with functional improvement, reduction in PANSS at week 5 (OR=1.02, 95% CI=1.01-1.03), and total IEQ score at baseline (OR=1.09, 95% CI=1.07-1.11) with caregiver burden reduction. Thus, symptom and functional improvements with caregiver burden reduction were observed in patients, and PANSS reduction at week 5 was commonly associated with favorable outcomes.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 15%
Researcher 3 15%
Student > Master 3 15%
Student > Doctoral Student 3 15%
Professor > Associate Professor 2 10%
Other 5 25%
Unknown 1 5%
Readers by discipline Count As %
Nursing and Health Professions 5 25%
Psychology 3 15%
Biochemistry, Genetics and Molecular Biology 3 15%
Medicine and Dentistry 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Other 2 10%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2018.
All research outputs
#11,520,237
of 14,537,474 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,845
of 2,487 outputs
Outputs of similar age
#208,958
of 277,835 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#57
of 80 outputs
Altmetric has tracked 14,537,474 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,487 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,835 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.