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Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Overview of attention for article published in International Journal of Nanomedicine, March 2018
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Mentioned by

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1 tweeter

Citations

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28 Dimensions

Readers on

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38 Mendeley
Title
Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers
Published in
International Journal of Nanomedicine, March 2018
DOI 10.2147/ijn.s156616
Pubmed ID
Authors

Dereje Kebebe, Yuanyuan Liu, Yumei Wu, Maikhone Vilakhamxay, Zhidong Liu, Jiawei Li

Abstract

Cancer has become one of the leading causes of mortality globally. The major challenges of conventional cancer therapy are the failure of most chemotherapeutic agents to accumulate selectively in tumor cells and their severe systemic side effects. In the past three decades, a number of drug delivery approaches have been discovered to overwhelm the obstacles. Among these, nanocarriers have gained much attention for their excellent and efficient drug delivery systems to improve specific tissue/organ/cell targeting. In order to enhance targeting efficiency further and reduce limitations of nanocarriers, nanoparticle surfaces are functionalized with different ligands. Several kinds of ligand-modified nanomedicines have been reported. Cell-penetrating peptides (CPPs) are promising ligands, attracting the attention of researchers due to their efficiency to transport bioactive molecules intracellularly. However, their lack of specificity and in vivo degradation led to the development of newer types of CPP. Currently, activable CPP and tumor-targeting peptide (TTP)-modified nanocarriers have shown dramatically superior cellular specific uptake, cytotoxicity, and tumor growth inhibition. In this review, we discuss recent advances in tumor-targeting strategies using CPPs and their limitations in tumor delivery systems. Special emphasis is given to activable CPPs and TTPs. Finally, we address the application of CPPs and/or TTPs in the delivery of plant-derived chemotherapeutic agents.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Ph. D. Student 5 13%
Student > Bachelor 4 11%
Student > Doctoral Student 3 8%
Professor > Associate Professor 3 8%
Other 9 24%
Unknown 7 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 16%
Chemistry 5 13%
Medicine and Dentistry 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Unspecified 2 5%
Other 6 16%
Unknown 12 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2018.
All research outputs
#10,154,829
of 12,706,057 outputs
Outputs from International Journal of Nanomedicine
#1,942
of 2,489 outputs
Outputs of similar age
#206,324
of 273,759 outputs
Outputs of similar age from International Journal of Nanomedicine
#33
of 47 outputs
Altmetric has tracked 12,706,057 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,489 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,759 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.