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Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety

Overview of attention for article published in Therapeutics and Clinical Risk Management, September 2009
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

wikipedia
2 Wikipedia pages

Citations

dimensions_citation
59 Dimensions

Readers on

mendeley
43 Mendeley
Title
Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety
Published in
Therapeutics and Clinical Risk Management, September 2009
DOI 10.2147/tcrm.s5189
Pubmed ID
Authors

Christoph Kellinghaus

Abstract

Lacosamide (LCM) is a novel agent that has been developed as an antiepileptic drug. In vitro studies suggest that LCM modulates voltage-gated sodium channels by enhancing their slow inactivation. In addition, LCM seems to interact with collapsin-response mediator protein 2 and thus may mediate neuronal plasticity. LCM has an elimination half-life of 13 hours, no relevant protein binding, and does not induce or inhibit enzymes of the cytochrome P450 system. No clinically significant drug-drug interactions have been discovered as yet. Experimental data suggest anticonvulsant as well as analgesic effects. Large clinical studies have demonstrated its efficacy for treatment of patients with partial seizures. LCM is well tolerated, and the most common adverse events are unspecific central nervous system and gastrointestinal effects such as dizziness, vertigo, nausea, and headache. LCM is approved for treatment of partial seizures with or without secondary generalization in the United States and the European Union within a dose range of 200 to 400 mg per day, administered twice daily. In addition to the oral formulations, an intravenous infusion solution is available.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Romania 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 21%
Student > Master 6 14%
Other 5 12%
Student > Doctoral Student 4 9%
Student > Ph. D. Student 4 9%
Other 11 26%
Unknown 4 9%
Readers by discipline Count As %
Medicine and Dentistry 22 51%
Neuroscience 6 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Biochemistry, Genetics and Molecular Biology 1 2%
Computer Science 1 2%
Other 3 7%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2016.
All research outputs
#817,816
of 3,627,006 outputs
Outputs from Therapeutics and Clinical Risk Management
#81
of 268 outputs
Outputs of similar age
#24,558
of 94,817 outputs
Outputs of similar age from Therapeutics and Clinical Risk Management
#3
of 15 outputs
Altmetric has tracked 3,627,006 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 268 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,817 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.