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Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness

Overview of attention for article published in International Journal of Nanomedicine, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

patent
8 patents

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
104 Mendeley
Title
Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness
Published in
International Journal of Nanomedicine, April 2015
DOI 10.2147/ijn.s77480
Pubmed ID
Authors

Igor Khalin, Ganna Kocherga, Muhamad Abu Bakar, Renad Alyautdin

Abstract

Neurodegenerative causes of blindness and deafness possess a major challenge in their clinical management as proper treatment guidelines have not yet been found. Brain-derived neurotrophic factor (BDNF) has been established as a promising therapy against neurodegenerative disorders including hearing and visual loss. Unfortunately, the blood-retinal barrier and blood-cochlear barrier, which have a comparable structure to the blood-brain barrier prevent molecules of larger sizes (such as BDNF) from exiting the circulation and reaching the targeted cells. Anatomical features of the eye and ear allow use of local administration, bypassing histo-hematic barriers. This paper focuses on highlighting a variety of strategies proposed for the local administration of the BDNF, like direct delivery, viral gene therapy, and cell-based therapy, which have been shown to successfully improve development, survival, and function of spiral and retinal ganglion cells. The similarities and controversies for BDNF treatment of posterior eye diseases and inner ear diseases have been analyzed and compared. In this review, we also focus on the possibility of translation of this knowledge into clinical practice. And finally, we suggest that using nanoparticulate drug-delivery systems may substantially contribute to the development of clinically viable techniques for BDNF delivery into the cochlea or posterior eye segment, which, ultimately, can lead to a long-term or permanent rescue of auditory and optic neurons from degeneration.

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
India 1 <1%
Germany 1 <1%
Unknown 101 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 20%
Student > Master 17 16%
Researcher 13 13%
Student > Bachelor 11 11%
Student > Doctoral Student 7 7%
Other 17 16%
Unknown 18 17%
Readers by discipline Count As %
Medicine and Dentistry 24 23%
Neuroscience 14 13%
Biochemistry, Genetics and Molecular Biology 10 10%
Agricultural and Biological Sciences 9 9%
Engineering 7 7%
Other 18 17%
Unknown 22 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2022.
All research outputs
#3,220,706
of 22,497,510 outputs
Outputs from International Journal of Nanomedicine
#197
of 3,751 outputs
Outputs of similar age
#41,965
of 243,284 outputs
Outputs of similar age from International Journal of Nanomedicine
#3
of 17 outputs
Altmetric has tracked 22,497,510 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,751 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.