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SYK expression level distinguishes control from BRCA1-mutated lymphocytes

Overview of attention for article published in Cancer Management and Research, March 2018
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Title
<em>SYK </em>expression level distinguishes control from <em>BRCA1</em>-mutated lymphocytes
Published in
Cancer Management and Research, March 2018
DOI 10.2147/cmar.s156359
Pubmed ID
Authors

Tamar Zahavi, Amir Sonnenblick, Yael Shimshon, Luna Kadouri, Tamar Peretz, Asher Y Salmon, Mali Salmon-Divon

Abstract

About 5%-10% of breast cancer and 10%-15% of ovarian cancer are hereditary.BRCA1andBRCA2are the most common germline mutations found in both inherited breast and ovarian cancers. Once these mutations are identified and classified, a course of action to reduce the risk of developing either ovarian or breast cancer - including surveillance and surgery - is carried out. The purpose of the current research is to characterize the gene expression differences between healthy cells harboring a mutation inBRCA1/2 genes and normal cells. This will allow detection of candidate genes and help identify women who carry functionalBRCA1/2 mutations, which cannot always be detected by the available sequencing methods, for example, carriers of mutations found in regulatory sequences of the genes. Our cohort consisted of 50 healthy women, of whom 24 were individuals withBRCA1orBRCA2heterozygous mutations and 26 were non-carrier controls. RNA purified from non-irradiated lymphocytes of nineBRCA1/2 mutation carriers versus four control mutation-negative individuals was utilized for RNA-Seq analysis. The selected RNA-Seq transcripts were validated, and the levels of spleen tyrosine kinase (SYK) mRNA were measured by using real-time quantitative polymerase chain reaction. Differences in gene expression were found when comparing untreated lymphocytes ofBRCA1/2mutation carriers and controls. Among others, theSYKgene was identified as being differently expressed forBRCA1/2 mutation carriers. The expression level ofSYKwas significantly higher in untreated healthy lymphocytes ofBRCA1heterozygote carriers compared with controls, regardless of irradiation. In contrast to normal tissues, in cancerous breast tissues, the expression levels of theBRCA1andSYKgenes were not intercorrelated. Collectively, our observations demonstrate thatSYKmay prove to be a good candidate for better diagnosis, treatment, and prevention ofBRCA1mutation-associated breast cancer.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 1 33%
Student > Ph. D. Student 1 33%
Researcher 1 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 67%
Agricultural and Biological Sciences 1 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2018.
All research outputs
#11,356,304
of 12,768,104 outputs
Outputs from Cancer Management and Research
#427
of 526 outputs
Outputs of similar age
#238,895
of 273,897 outputs
Outputs of similar age from Cancer Management and Research
#34
of 36 outputs
Altmetric has tracked 12,768,104 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 526 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.