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Neuroprotective strategies against calpain-mediated neurodegeneration

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

twitter
2 tweeters
patent
2 patents

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
71 Mendeley
Title
Neuroprotective strategies against calpain-mediated neurodegeneration
Published in
Neuropsychiatric Disease and Treatment, February 2015
DOI 10.2147/ndt.s78226
Pubmed ID
Authors

Ayşegül Yildiz-Unal, Sirin Korulu, Arzu Karabay

Abstract

Calpains are calcium-dependent proteolytic enzymes that have deleterious effects on neurons upon their pathological over-activation. According to the results of numerous studies to date, there is no doubt that abnormal calpain activation triggers activation and progression of apoptotic processes in neurodegeneration, leading to neuronal death. Thus, it is very crucial to unravel all the aspects of calpain-mediated neurodegeneration in order to protect neurons through eliminating or at least minimizing its lethal effects. Protecting neurons against calpain-activated apoptosis basically requires developing effective, reliable, and most importantly, therapeutically applicable approaches to succeed. From this aspect, the most significant studies focusing on preventing calpain-mediated neurodegeneration include blocking the N-methyl-d-aspartate (NMDA)-type glutamate receptor activities, which are closely related to calpain activation; directly inhibiting calpain itself via intrinsic or synthetic calpain inhibitors, or inhibiting its downstream processes; and utilizing the neuroprotectant steroid hormone estrogen and its receptors. In this review, the most remarkable neuroprotective strategies for calpain-mediated neurodegeneration are categorized and summarized with respect to their advantages and disadvantages over one another, in terms of their efficiency and applicability as a therapeutic regimen in the treatment of neurodegenerative diseases.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 23%
Student > Master 15 21%
Student > Ph. D. Student 14 20%
Researcher 8 11%
Other 3 4%
Other 6 8%
Unknown 9 13%
Readers by discipline Count As %
Medicine and Dentistry 15 21%
Agricultural and Biological Sciences 14 20%
Biochemistry, Genetics and Molecular Biology 10 14%
Neuroscience 10 14%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 9 13%
Unknown 10 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2022.
All research outputs
#6,194,945
of 22,512,567 outputs
Outputs from Neuropsychiatric Disease and Treatment
#797
of 2,960 outputs
Outputs of similar age
#81,151
of 326,987 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#20
of 68 outputs
Altmetric has tracked 22,512,567 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,960 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.