Title |
Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial
|
---|---|
Published in |
International Journal of Chronic Obstructive Pulmonary Disease, January 2015
|
DOI | 10.2147/copd.s76061 |
Pubmed ID | |
Authors |
Michelle E John, John R Cockcroft, Tricia M McKeever, William R Coward, Dennis J Shale, Simon R Johnson, Jim G Thornton, Timothy W Harrison, Alan J Knox, Charlotte E Bolton |
Abstract |
There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the disease. Statins modulate aortic stiffness and have anti-inflammatory properties. A proof-of-principle, double-blind, randomized trial determined if 6 weeks of simvastatin 20 mg once daily reduced aortic stiffness and systemic and airway inflammation in patients with chronic obstructive pulmonary disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Netherlands | 1 | 2% |
Italy | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 16% |
Researcher | 7 | 12% |
Student > Ph. D. Student | 5 | 9% |
Student > Bachelor | 5 | 9% |
Student > Doctoral Student | 3 | 5% |
Other | 13 | 23% |
Unknown | 15 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 23% |
Nursing and Health Professions | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Unspecified | 3 | 5% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 11 | 19% |
Unknown | 20 | 35% |