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Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice

Overview of attention for article published in International Journal of Nanomedicine, February 2015
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  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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2 tweeters

Citations

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14 Dimensions

Readers on

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47 Mendeley
Title
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice
Published in
International Journal of Nanomedicine, February 2015
DOI 10.2147/ijn.s76317
Pubmed ID
Authors

Paula Melariri, Lonji Kalombo, Patric Nkuna, Adimre Dube, Rose Hayeshi, Benhards Ogutu, Liezl Gibhard, Carmen deKock, Peter Smith, Lubbe Weisner, Hulda Swai

Abstract

Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ (MTQ) with sizes <20 nm improved the solubility of TQ and enhanced the oral bioavailability from 55% to 99% in healthy mice (area under the curve 0 to infinity: 11,368±1,232 and 23,842±872 min·μmol/L) for reference TQ and MTQ, respectively. Average parasitemia in Plasmodium berghei-infected mice was four- to tenfold lower in the MTQ-treated group. In vitro antiplasmodial activities against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum indicated no change in half maximal inhibitory concentration, suggesting that the microemulsion did not affect the inherent activity of TQ. In a humanized mouse model of G6PD deficiency, we observed reduction in toxicity of TQ as delivered by MTQ at low but efficacious concentrations of TQ. We hereby report an enhancement in the solubility, bioavailibility, and efficacy of TQ against blood stages of Plasmodium parasites without a corresponding increase in toxicity.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
South Africa 1 2%
Unknown 45 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 28%
Researcher 9 19%
Student > Master 4 9%
Student > Bachelor 3 6%
Student > Doctoral Student 3 6%
Other 11 23%
Unknown 4 9%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 13 28%
Medicine and Dentistry 5 11%
Engineering 5 11%
Chemistry 5 11%
Biochemistry, Genetics and Molecular Biology 3 6%
Other 12 26%
Unknown 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#7,498,534
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#1,088
of 2,456 outputs
Outputs of similar age
#109,274
of 219,667 outputs
Outputs of similar age from International Journal of Nanomedicine
#9
of 24 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,667 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.